LE Lo, R Kaur, B Meiser, Mj Green
Psychosocial Research Group, Prince of Wales Clinical School, Sydney, NSW, Australia.
Psychosocial Research Group, Prince of Wales Clinical School, Sydney, NSW, Australia.
Psychiatry Res. 2020 Feb 5;286:112852. doi: 10.1016/j.psychres.2020.112852.
A meta-analysis was conducted to estimate schizophrenia incidence in first-degree relatives (FDRs) of probands diagnosed with schizophrenia. The aim was to inform future schizophrenia research and improve accuracy of risk communication to patients. Schizophrenia risk in FDRs with 1 or 2 probands with schizophrenia was investigated by conducting a systematic review of cohort and case-control studies with the following criteria: published between 1977 and 2018; reported odds ratios (OR), relative risk (RR) or sufficient raw data to calculate OR or RR; used appropriate diagnostic criteria; and reported systematic proband recruitment and ascertainment of relatives. Studies were obtained via EMBASE and MEDLINE electronic database searches. From an initial 5755 articles, 19 met the inclusion criteria. Mean effect sizes across studies were estimated using random effects methods. Estimates for schizophrenia risk were OR = 7.69 (95% CI 5.11-11.56) for FDRs of one proband with schizophrenia compared to healthy control probands, increasing to OR = 11.11 (95% CI = 1.45-85.02) for FDRs with two probands with schizophrenia. These findings support the existing literature suggesting significant genetic liability for schizophrenia. The results can be used to educate individuals with a family history of schizophrenia about their risk.
开展了一项荟萃分析，以估计被诊断为精神分裂症的先证者的一级亲属（FDR）中精神分裂症的发病率。目的是为未来的精神分裂症研究提供信息，并提高向患者进行风险沟通的准确性。通过对队列研究和病例对照研究进行系统评价，调查有1名或2名精神分裂症先证者的FDR患精神分裂症的风险，评价标准如下：发表于1977年至2018年之间；报告了比值比（OR）、相对风险（RR）或有足够的原始数据来计算OR或RR；使用了适当的诊断标准；报告了系统的先证者招募和亲属确定情况。通过EMBASE和MEDLINE电子数据库检索获取研究。从最初的5755篇文章中，有19篇符合纳入标准。使用随机效应方法估计各项研究的平均效应量。与健康对照先证者相比，有1名精神分裂症先证者的FDR患精神分裂症的风险估计值为OR = 7.69（95%CI 5.11 - 11.56），有2名精神分裂症先证者的FDR的该风险估计值增至OR = 11.11（95%CI = 1.45 - 85.02）。这些发现支持了现有文献，表明精神分裂症存在显著的遗传易感性。这些结果可用于对有精神分裂症家族史的个体进行风险教育。
