University of Wyoming School of Pharmacy, 1000 East University Avenue, Department 3375, Laramie, WY, 82071, USA.
Sci Rep. 2020 Feb 17;10(1):2762. doi: 10.1038/s41598-020-59628-6.
More than a quarter of a million individuals in the US live with spinal cord injury (SCI). SCI disrupts neural circuitry to vital organs in the body. Despite severe incidences of long-term peripheral complications from SCI, the cardio-metabolic consequences and divergences in sex-related responses are not well described. We examined the effects of SCI on functional recovery, cardiac structure and function, body composition, and glucose metabolism on adult female and male Sprague Dawley (SD) rats. SCI was induced at T10 via contusion. Measured outcomes include behavioral assessment, body weight, dual-energy X-ray absorptiometry (DEXA) for body composition, echocardiography for cardiac structure and function, intraperitoneal glucose tolerance test (IPGTT) for glucose metabolism, insulin tolerance test (ITT), and histology of cardiac structure at the endpoint. There was a decrease in body fat percentage in both sexes, with SCI females disproportionately affected in percent body fat change. Left ventricular internal diameter during systole (LVIDs) was decreased in SCI females more than in SCI males. No significant differences in glucose metabolism were observed up to 20 weeks post-injury (PI). These data show significant cardio-metabolic differences as a consequence of SCI and, furthermore, that sex is an underlying factor in these differences.
美国有超过 25 万人患有脊髓损伤 (SCI)。SCI 破坏了身体重要器官的神经回路。尽管 SCI 会导致长期严重的外周并发症，但心肺代谢的后果和性别相关反应的差异尚未得到很好的描述。我们研究了 SCI 对成年雌性和雄性 Sprague Dawley (SD) 大鼠的功能恢复、心脏结构和功能、身体成分和葡萄糖代谢的影响。通过挫伤在 T10 处诱导 SCI。测量结果包括行为评估、体重、双能 X 射线吸收法 (DEXA) 用于身体成分、超声心动图用于心脏结构和功能、腹腔内葡萄糖耐量试验 (IPGTT) 用于葡萄糖代谢、胰岛素耐量试验 (ITT) 以及心脏结构的组织学在终点。两性的体脂百分比都有所下降，SCI 女性的体脂百分比变化不成比例。SCI 女性的收缩期左室内径 (LVIDs) 比 SCI 男性下降更多。在损伤后 20 周内，葡萄糖代谢没有明显差异。这些数据显示，SCI 会导致明显的心肺代谢差异，而且，性别是这些差异的一个潜在因素。
