Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Medicinal Plants, Imam Khomeini Higher Education Center, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Comb Chem High Throughput Screen. 2020;23(3):191-195. doi: 10.2174/1386207323666200218113537.
Clinoptilolite is one of the natural zeolites. Clinoptilolite particles have a high surface area, negative surface charge, cation adsorption and exchange capacities. Barium sulfate (BaSO4) and bismuth subnitrate (Bi5H9N4O22) suspensions have been used for upper and lower gastrointestinal imaging but Ba2+ and Bi3+ ions are toxic. In the present study, the feasibility of the application of Ba2+- and Bi3+-loaded clinoptilolite micro- and nano-particles in medical imaging was investigated.
Nanoparticles and microparticles of natural clinoptilolite were loaded with Ba2+ and Bi3+ ions. Radiopacities of loaded particles were measured and compared with those of BaSO4 and Bi5H9N4O22.
Ba2+- and Bi3+-loaded clinoptilolite nanoparticles and microparticles showed more intense X-ray opacities than BaSO4 and Bi5H9N4O22 with equimolar concentrations. Moreover, Ba2+- and Bi3+-loaded clinoptilolite nanoparticles more intensely absorbed X-ray than respective loaded microparticles.
The present study proposes Ba2+- and Bi3+-loaded clinoptilolite nanoparticles and microparticles as new, safe, efficient, and inexpensive contrast agents.
斜发沸石是天然沸石之一。斜发沸石颗粒具有高表面积、负表面电荷、阳离子吸附和交换能力。硫酸钡 (BaSO4) 和亚硝酸铋 (Bi5H9N4O22) 混悬液已用于上消化道和下消化道成像，但 Ba2+ 和 Bi3+ 离子是有毒的。在本研究中，研究了负载 Ba2+ 和 Bi3+ 的斜发沸石纳米和微颗粒在医学成像中的应用的可行性。
用 Ba2+ 和 Bi3+ 离子负载天然斜发沸石的纳米颗粒和微颗粒。测量负载颗粒的射线不透明度，并与 BaSO4 和 Bi5H9N4O22 进行比较。
等摩尔浓度下，负载 Ba2+ 和 Bi3+ 的斜发沸石纳米颗粒和微颗粒比 BaSO4 和 Bi5H9N4O22 显示出更强的 X 射线不透明度。此外，负载 Ba2+ 和 Bi3+ 的斜发沸石纳米颗粒比相应的负载微颗粒更强烈地吸收 X 射线。
本研究提出负载 Ba2+ 和 Bi3+ 的斜发沸石纳米颗粒和微颗粒作为新型、安全、高效和廉价的对比剂。
