Waterhouse Nicole N, Kothari Paresh J, Dooley Marybeth, Hu Bao, de Leon Mony J, Babich John, Qu Wenchao
Citigroup Biomedical Imaging Center, Weill Cornell Medicine, New York, NY, USA.
Citigroup Biomedical Imaging Center, Weill Cornell Medicine, New York, NY, USA; Division of Radiopharmaceutical Sciences, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Appl Radiat Isot. 2020 May;159:109078. doi: 10.1016/j.apradiso.2020.109078. Epub 2020 Feb 8.
A facile synthesis method for the preparation of [1-C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.
开发了一种用于制备区域脑血流显像剂[1-C]丁醇的简便合成方法。采用固相萃取法，高极性挥发性分子[1-C]丁醇可快速浓缩、纯化并作为最终产品释放；具有高放射化学纯度、化学纯度以及高放射化学产率。最终药品为符合美国药典（USP）<823>要求的无菌、无热原溶液。
