3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.
Colloids and Polymers Physics Group, Department of Condensed Matter Physics, Faculty of Physics, University of Santiago de Compostela, Campus Vida, E-15782-Santiago de Compostela, Spain.
Chem Commun (Camb). 2020 Mar 12;56(21):3187-3190. doi: 10.1039/d0cc00192a.
The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.
二氢芝麻素和芝麻林素异构体可保护 SH-SY5Y 细胞免受 Aβ42 介导的死亡。由于二氢芝麻素 C1 位糖链上的 OH 基团的空间组织，使其能够更好地实现这一点，从而提高其重塑有毒 Aβ42 寡聚物二级结构的能力。
