Nanostructured Materials Laboratory, University of Georgia, Athens, GA, 30602, USA.
Department of Chemistry, The University of Georgia, Athens, GA, 30602, USA.
Small. 2020 Mar;16(11):e1907422. doi: 10.1002/smll.201907422. Epub 2020 Feb 18.
This work introduces a gravity fiber drawing (GFD) method of making single filament nanofibers from polymer solutions and precise alignment of the fibers in 3D scaffolds. This method is advantageous for nanofiber 3D alignment in contrast to other known methods. GFD provides a technology for the fabrication of freestanding filament nanofibers of well-controlled diameter, draw ratio, and 3D organization with controllable spacing and angular orientation between nanofibers. The GFD method is capable of fabricating complex 3D scaffolds combining fibers with different diameters, chemical compositions, mechanical properties, angular orientations, and multilayer structures in the same construct. The scaffold porosity can be as high as 99% to secure transport of nutrients and space for cell infiltration and differentiation in tissue engineering and 3D cell culture applications.
这项工作介绍了一种从聚合物溶液中制造单丝纳米纤维的重力纤维拉伸（GFD）方法，以及纤维在 3D 支架中的精确排列。与其他已知方法相比，这种方法有利于纳米纤维的 3D 排列。GFD 为制造具有可控直径、拉伸比和 3D 组织的独立长丝纳米纤维提供了一种技术，并且可以控制纳米纤维之间的间距和角向取向。GFD 方法能够制造复杂的 3D 支架，将具有不同直径、化学成分、机械性能、角向取向和多层结构的纤维结合在同一结构中。支架的孔隙率可以高达 99%，以确保在组织工程和 3D 细胞培养应用中营养物质的传输和细胞渗透和分化的空间。
