有丝分裂原激活的蛋白激酶（MAPK）与肥胖相关癌症。
Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer.
机构信息
Ireland East Hospital Gynaeoncology Group, UCD School of Medicine, Mater Misericordiae University, D07R2WY Dublin 7, Ireland.
Queensland Centre for Gynaecological Cancer Research, The University of Queensland, Brisbane QLD 4029, Australia.
出版信息
Int J Mol Sci. 2020 Feb 13;21(4):1241. doi: 10.3390/ijms21041241.
Abstract
Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and obesity-related cancer. We focus mostly on p38 and JNK MAPK, as the role of ERK remains unclear. These links are seen through the implication of MAPK in obesity-related immune paralysis as well as through effects on the endoplasmic reticulum stress response and activation of aromatase. By way of example, we highlight areas of interest and possibilities for future research in endometrioid endometrial cancer and hepatocellular carcinoma associated with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and MAPK.
摘要
肥胖是全球范围内一个主要的公共卫生关注点。尽管其分子机制尚不完全清楚，但肥胖会增加某些类型癌症的风险，这已被确定为其有害后果。在这篇综述中，我们旨在探讨 MAPK 信号与肥胖相关癌症之间的联系。我们主要关注 p38 和 JNK MAPK，因为 ERK 的作用尚不清楚。这些联系可以通过 MAPK 在肥胖相关免疫麻痹中的作用以及对内质网应激反应和芳香酶激活的影响来看出来。举例来说，我们强调了与非酒精性脂肪性肝病 (NAFLD)、非酒精性脂肪性肝炎 (NASH) 和 MAPK 相关的子宫内膜样子宫内膜癌和肝细胞癌的研究领域的关注点和未来研究的可能性。
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