Muráth Szabolcs, Szerlauth Adél, Sebők Dániel, Szilágyi István
MTA-SZTE Lendület Biocolloids Research Group, University of Szeged, H-6720 Szeged, Hungary.
Department of Physical Chemistry and Materials Science, Interdisciplinary Excellence Center, University of Szeged, H-6720 Szeged, Hungary.
Antioxidants (Basel). 2020 Feb 13;9(2):153. doi: 10.3390/antiox9020153.
Ellagic acid (EA), a polyphenolic antioxidant of poor water solubility, was intercalated into biocompatible layered double hydroxide (LDH) nanoparticles by the coprecipitation method. Structural investigation of the composite revealed that the lactone bonds split under the synthetic experimental conditions, and EA was transformed to 4,4',5,5',6,6'-hexahydroxydiphenic acid during intercalation. To improve the surface properties of the EA-LDH composite, the samples were treated with different organic solvents. The antioxidant activity of the LDH hybrids was assessed in test reactions. Most of the obtained hybrids showed antioxidant activity comparable to the one of the free EA indicating that the spontaneous structural transformation upon immobilization did not change the efficiency in radical scavenging. Treatments with organic solvents influenced the activities of the materials remarkably. The main advantage of the immobilization procedure is that the products can be applied in aqueous samples in high concentrations overcoming the problem related to the low solubility of EA in water. The developed composites of high antioxidant content can be applied as efficient reactive oxygen species scavenging materials during biomedical treatments or industrial manufacturing processes.
鞣花酸（EA）是一种水溶性较差的多酚类抗氧化剂，通过共沉淀法将其嵌入生物相容性层状双氢氧化物（LDH）纳米颗粒中。对该复合材料的结构研究表明，内酯键在合成实验条件下断裂，且在嵌入过程中EA转化为4,4',5,5',6,6'-六羟基二苯酸。为改善EA-LDH复合材料的表面性质，用不同有机溶剂对样品进行处理。在测试反应中评估了LDH杂化物的抗氧化活性。大多数所得杂化物表现出与游离EA相当的抗氧化活性，这表明固定化时的自发结构转变并未改变其清除自由基的效率。用有机溶剂处理对材料的活性有显著影响。固定化过程的主要优点是产物可高浓度应用于水性样品中，克服了EA在水中溶解度低的问题。所开发的具有高抗氧化剂含量的复合材料可在生物医学治疗或工业制造过程中用作高效的活性氧清除材料。
