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卫星细胞激活通过一氧化氮信号在异位口面超敏反应中的作用。

Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity.

机构信息

Department of Complete Denture Prosthodontics, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.

Department of Endodontics, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.

出版信息

Int J Mol Sci. 2020 Feb 13;21(4):1252. doi: 10.3390/ijms21041252.

DOI:10.3390/ijms21041252
PMID:32070010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7072927/
Abstract

The mechanical head-withdrawal threshold (MHWT) was significantly reduced following inferior alveolar nerve transection (IANX) in rats. Nitrate and nitrite synthesis was dramatically increased in the trigeminal ganglion (TG) at 6 h after the IANX. The relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells was significantly higher in IANX rats compared to sham-operated and N-propyl-L-arginine (NPLA)-treated IANX rats. On day 3 after NPLA administration, the MHWT recovered considerably in IANX rats. Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher. The relative number of nNOS-IR cells encircled by GFAP-IR cells was significantly increased in IANX rats. In contrast, after NPLA injection into the TG, the relative number of GFAP-IR cells was considerably reduced in IANX rats. Fluorocitrate administration into the TG significantly reduced the number of GFAP-IR cells and prevented the MHWT reduction in IANX rats. The present findings suggest that following IANX, satellite glial cells are activated via nitric oxide (NO) signaling from TG neurons. The spreading satellite glial cell activation within the TG results in mechanical hypersensitivity of face regions not directly associated with the trigeminal nerve injury.

摘要

在下颌神经切断术后，机械性头部撤回阈值（MHWT）显著降低。在切断术后 6 小时，三叉神经节（TG）中硝酸盐和亚硝酸盐的合成显著增加。与假手术和 N-丙基-L-精氨酸（NPLA）治疗的 IANX 大鼠相比，IANX 大鼠 TG 中神经元型一氧化氮合酶（nNOS）免疫反应（IR）细胞的相对数量明显更高。在 NPLA 给药后第 3 天，IANX 大鼠的 MHWT 恢复相当大。在将 L-精氨酸注入 TG 后，MHWT 在 15 分钟内显著降低，并且被胶质纤维酸性蛋白（GFAP）-IR 细胞包围的 TG 细胞的平均数量显著更高。IANX 大鼠中被 GFAP-IR 细胞包围的 nNOS-IR 细胞的相对数量显著增加。相比之下，在将 NPLA 注入 TG 后，IANX 大鼠的 GFAP-IR 细胞的相对数量大大减少。将氟代柠檬酸注入 TG 可显著减少 GFAP-IR 细胞的数量，并防止 IANX 大鼠的 MHWT 降低。这些发现表明，在 IANX 之后，卫星胶质细胞通过来自 TG 神经元的一氧化氮（NO）信号而被激活。TG 内卫星胶质细胞的扩散激活导致与三叉神经损伤无直接关系的面部区域的机械性过敏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/4141f49fa75d/ijms-21-01252-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/db6c204ae557/ijms-21-01252-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/78e935b0a88a/ijms-21-01252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/5a446486a6c3/ijms-21-01252-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/d0d5c0dafbd2/ijms-21-01252-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/b2ed87b27812/ijms-21-01252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/20f1bdcbe27b/ijms-21-01252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/d7690fe24f1e/ijms-21-01252-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/bc771bb5beb3/ijms-21-01252-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/4141f49fa75d/ijms-21-01252-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/db6c204ae557/ijms-21-01252-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/78e935b0a88a/ijms-21-01252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/5a446486a6c3/ijms-21-01252-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/d0d5c0dafbd2/ijms-21-01252-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/b2ed87b27812/ijms-21-01252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/20f1bdcbe27b/ijms-21-01252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/d7690fe24f1e/ijms-21-01252-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/bc771bb5beb3/ijms-21-01252-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b26/7072927/4141f49fa75d/ijms-21-01252-g009.jpg

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