舞蹈症小鼠突变体中与年龄相关的听觉脑干反应（ABR）阈值变化。

Age-related auditory brainstem response (ABR) threshold changes in the dancer mouse mutant.

作者信息

Wenngren B I, Anniko M

机构信息

Department of Oto-Rhino-Laryngology, University Hospital, Umeå, Sweden.

出版信息

Acta Otolaryngol. 1988 Nov-Dec;106(5-6):386-92. doi: 10.3109/00016488809122261.

DOI:10.3109/00016488809122261

PMID:3207006

Abstract

An age-related analysis of auditory brainstem response (ABR) thresholds in 42 heterozygotic dancer mouse mutants (1-13 months old) showed an impairment of ABR thresholds with increasing age, though individual threshold curves could vary considerably. As compared with normal CBA/CBA mice, a progressive deterioration of ABR thresholds occurred from the 2nd postnatal month onwards. The dancer mutant has an inner ear with a morphogenetic type of defect, caused by a semidominant gene which is located in chromosome 19.

摘要

对42只杂合子舞蹈小鼠突变体（1至13月龄）进行的听觉脑干反应（ABR）阈值的年龄相关性分析显示，ABR阈值会随着年龄增长而受损，尽管个体阈值曲线可能有很大差异。与正常的CBA/CBA小鼠相比，出生后第2个月起ABR阈值出现渐进性恶化。舞蹈小鼠突变体的内耳存在形态发生类型的缺陷，由位于19号染色体上的一个半显性基因引起。