Mittal Hitisha, Wyawahare Mukta, Sistla Sujata
MBBS Student, Department of Medicine, JIPMER, Pondicherry, India.
Additional Professor, Department of Medicine, JIPMER, Pondicherry, India.
Trop Doct. 2020 Apr;50(2):138-141. doi: 10.1177/0049475520905745. Epub 2020 Feb 18.
Spontaneous bacterial peritonitis (SBP) is an acute bacterial infection of ascitic fluid without an obvious source. The prevalence of SBP in patients with cirrhosis is in the range of 10%-30%. With increasing use of antibiotics, there is a gradual shift in the causative flora of SBP from Gram-negative bacteria to Gram-positive and, more importantly, to drug-resistant bacteria. The aim of this retrospective study on 721 cases was to identify the prevalence of various organisms causing SBP along with their drug sensitivity and resistance patterns. A prevalence of 38.2% culture positivity was observed in our South Indian population. was the most common pathogen isolated. Third-generation cephalosporins showed high rates of resistance, but a susceptibility of 74.5% to amikacin was found. Nonetheless, 42% of culture-positive isolates exhibited multidrug resistance, the highest rates being seen with (64.2%) and (71.4%).
自发性细菌性腹膜炎（SBP）是一种腹水的急性细菌感染，无明显感染源。肝硬化患者中SBP的患病率在10%至30%之间。随着抗生素的使用增加，SBP的致病菌群逐渐从革兰氏阴性菌转变为革兰氏阳性菌，更重要的是，转变为耐药菌。这项对721例病例的回顾性研究旨在确定引起SBP的各种生物体的患病率及其药敏和耐药模式。在我们的南印度人群中观察到培养阳性率为38.2%。 是分离出的最常见病原体。第三代头孢菌素显示出较高的耐药率，但发现对阿米卡星的敏感性为74.5%。尽管如此，42%的培养阳性分离株表现出多重耐药性，其中 （64.2%）和 （71.4%）的耐药率最高。
