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乳酸菌冻干粉治疗小儿细菌性腹膜炎对免疫功能和营养状况的影响

Effect of freeze-dried powder of lactic acid bacteria treatment of pediatric bacterial peritonitis on immune function and nutritional status.

作者信息

Xue Yang, Zhang YuTing

机构信息

Department of Pediatrics, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.

Department of Oncology Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China.

出版信息

Eur J Med Res. 2025 Jun 5;30(1):452. doi: 10.1186/s40001-025-02712-2.

DOI:10.1186/s40001-025-02712-2
PMID:40474200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12139331/
Abstract

OBJECTIVES

This study was to investigate the effects of freeze-dried powder of lactic acid bacteria treatment of pediatric bacterial peritonitis on immune function and nutritional status.

METHODS

100 cases of bacterial peritonitis children from September 2020 to September 2021 were included and divided into a control group and an observation group using a randomized numerical table, with each group containing 50 cases. The control group was given routine treatment such as antimicrobial drugs, and the observation group was given adjuvant treatment of freeze-dried powder of lactic acid bacteria. The clinical efficacy, immune function, nutritional status, inflammatory response, intestinal dysbiosis, and endotoxin level were compared between the two groups.

RESULTS

The total clinical effective rate of the observation group was higher than that of the control group. The ratio of CD3, CD4, and CD4/CD8 and the levels of ALB, TP, and Hb after treatment of the observation group were higher than those of the control group. CRP, PCT, and MCP-1 of the observation group were lower than those of the control group after treatment. Intestinal flora dysbiosis in the observation group was attenuated, and endotoxin level was reduced compared to the control group. No drug-related adverse reactions were observed in both groups during treatment.

CONCLUSIONS

Freeze-dried powder of lactic acid bacteria can improve immune function and nutritional status, as well as reduce inflammatory response and intestinal flora dysbiosis in pediatric bacterial peritonitis.

摘要

目的

本研究旨在探讨乳酸菌冻干粉治疗小儿细菌性腹膜炎对免疫功能和营养状况的影响。

方法

纳入2020年9月至2021年9月的100例细菌性腹膜炎患儿，采用随机数字表法分为对照组和观察组，每组50例。对照组给予抗菌药物等常规治疗，观察组给予乳酸菌冻干粉辅助治疗。比较两组的临床疗效、免疫功能、营养状况、炎症反应、肠道菌群失调及内毒素水平。

结果

观察组的总临床有效率高于对照组。观察组治疗后CD3、CD4及CD4/CD8比值以及ALB、TP和Hb水平均高于对照组。观察组治疗后CRP、PCT及MCP-1低于对照组。与对照组相比，观察组肠道菌群失调减轻，内毒素水平降低。治疗期间两组均未观察到与药物相关的不良反应。

结论

乳酸菌冻干粉可改善小儿细菌性腹膜炎的免疫功能和营养状况，同时减轻炎症反应和肠道菌群失调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/2835c5eca7d2/40001_2025_2712_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/587b9762c70f/40001_2025_2712_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/2bf774b1f651/40001_2025_2712_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/9f29e12989dd/40001_2025_2712_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/2835c5eca7d2/40001_2025_2712_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/587b9762c70f/40001_2025_2712_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/2bf774b1f651/40001_2025_2712_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/9f29e12989dd/40001_2025_2712_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0f/12139331/2835c5eca7d2/40001_2025_2712_Fig4_HTML.jpg

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