心脏神经嵴。
Cardiac Neural Crest.
机构信息
Division of Pediatric Cardiology, Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
出版信息
Cold Spring Harb Perspect Biol. 2021 Jan 4;13(1):a036715. doi: 10.1101/cshperspect.a036715.
Abstract
Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.
摘要
心脏神经嵴（CNC）细胞是多能细胞，来源于背侧神经管，迁移并有助于咽弓动脉的重塑和心流出道（OFT）的分隔。许多分子级联调节 CNC 的诱导、特化、分层和迁移。从鸡消融模型到分子生物学研究的对 CNC 的广泛分析探讨了心脏发育和疾病的机制，特别是涉及 OFT 和主动脉弓（AA）系统。最近的研究更多地集中在 CNC 与源自第二心脏场（SHF）的细胞之间的相互信号转导，这对于 OFT 心肌的发育至关重要，为先天性心脏病（CHD）和一些人类综合征的分子机制提供了新的见解。
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2
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PLoS One. 2015 Aug 21;10(8):e0136518. doi: 10.1371/journal.pone.0136518. eCollection 2015.
3
A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.染色质重塑因子CHD7在心血管发育过程中前中胚层发挥关键作用。
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