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sFRP2 在心脏发育和心血管疾病中的多重作用。

Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease.

机构信息

Department of Cardiology, Shunde hospital, Southern Medical University, Jiazi Road 1 Lunjiao Town, Shunde District, Foshan, Guangdong, 528308, China.

Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou.

出版信息

Int J Biol Sci. 2020 Jan 14;16(5):730-738. doi: 10.7150/ijbs.40923. eCollection 2020.

DOI:10.7150/ijbs.40923
PMID:32071544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7019133/
Abstract

The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease.

摘要

Wnt 信号通路在器官发育和疾病过程中发挥着重要作用。分泌型卷曲相关蛋白 2（sFRP2）是 Wnt 信号的重要分子，可调节心脏发育和心血管疾病。最近的研究表明，sFRP2 不仅是经典 Wnt 信号通路的拮抗剂，而且在心肌纤维化、血管生成、心脏肥大和心脏再生中具有更复杂的关系。本文综述了 sFRP2 和 Wnt 信号在心脏发育和心血管疾病中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/a15d514322d4/ijbsv16p0730g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/5c6689dd75f7/ijbsv16p0730g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/9518beb5fef6/ijbsv16p0730g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/a15d514322d4/ijbsv16p0730g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/5c6689dd75f7/ijbsv16p0730g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/9518beb5fef6/ijbsv16p0730g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b634/7019133/a15d514322d4/ijbsv16p0730g003.jpg

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