Bortnick Eric M, Simma-Chiang Vannita, Kaplan Steven A
Department of Urology, Mount Sinai Hospital, Icahn School of Medicine New York, NY.
Rev Urol. 2019;21(4):154-157.
Benign prostatic hyperplasia (BPH) is a common disease in men. Although transurethral resection of the prostate (TURP) is the gold standard therapy for treatment of BPH and associated lower urinary tract symptoms (LUTS), many patients choose to avoid surgery and instead choose medical therapy. Until recently, medical therapy for BPH has been thought to be both safe and effective. However, new studies have shown that some of these medications can have significant neurocognitive, psychiatric, and sexual side effects, including dementia and depression. As most patients taking these medications will continue them for the long term, it is vital for physicians to explain these potential risks to the patient prior to prescribing them for a quality-of-life condition.
良性前列腺增生（BPH）是男性的一种常见疾病。尽管经尿道前列腺切除术（TURP）是治疗BPH及相关下尿路症状（LUTS）的金标准疗法，但许多患者选择避免手术，而是选择药物治疗。直到最近，BPH的药物治疗一直被认为是安全有效的。然而，新的研究表明，其中一些药物可能会产生严重的神经认知、精神和性方面的副作用，包括痴呆和抑郁。由于大多数服用这些药物的患者将长期持续用药，因此医生在为改善生活质量的病情开这些药物之前，向患者解释这些潜在风险至关重要。
