Nozue A T
Department of Anatomy, Tokyo Medical and Dental University, Japan.
Anat Anz. 1988;167(2):165-9.
Multiple neural crest tumors, hyperplasia, excessive cell proliferation, the cell death of neural crest cells and melanin pigmentation occurred in newborn mice injected intraperitoneally with heated deionized water. It is thought that these phenomena may not only be associated with the protein denaturation of the membrane structure in the neural crest cells, but also with temperature dependent changes of lipid-lipid and lipid-protein interactions, particularly changes of the mobility of proteins, and that may be a reflection of thermodynamic decrease in entropy that occurs during differentiation.
给新生小鼠腹腔注射加热的去离子水后，出现了多个神经嵴肿瘤、增生、细胞过度增殖、神经嵴细胞死亡以及黑色素沉着。据认为，这些现象可能不仅与神经嵴细胞膜结构的蛋白质变性有关，还与脂质-脂质和脂质-蛋白质相互作用的温度依赖性变化有关，特别是蛋白质流动性的变化，这可能反映了分化过程中发生的热力学熵减少。
