Wilkinson M, Murphy S, Sinclair P, Heneghan H, le Roux C W, Brennan D J
Department of Gynaecological Oncology, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland.
Diabetes Complications Research Centre, Conway Institute, University College Dublin, Ireland.
Gynecol Oncol Rep. 2020 Jan 31;32:100545. doi: 10.1016/j.gore.2020.100545. eCollection 2020 May.
Obesity is the greatest risk factor for endometrial cancer. There is often a lack of recognition amongst patients about this risk. Evidence for weight-loss in the management of endometrial cancer is emerging. This was questionnaire-based study, that examined opinions and attitudes of patients with endometrial cancer and obesity towards obesity as a risk factor for cancer as well as examining their willingness to engage in weight loss interventions as an alternative treatment to endometrial cancer. This survey was conducted in a gynaeoncology out-patient department in Ireland. A total of 45/50 (90%) of questionnaires were completed. The majority of the patients questioned (86.7%; 39/45) agreed that obesity is a disease. Just over half of the cohort (53.3%; 24/45) believed that obesity can cause cancer. Over one-third, 39.9% (18/45) either disagreed or strongly disagreed that obesity is a risk factor for endometrial cancer while 35.5% (16/45) agreed or strongly agreed. Two-thirds (66.6%; 30/45) knew that the greatest amount of weight could be lost through metabolic surgery. Over three-quarters (82.1%; 37/45) of patients surveyed would be willing to engage in a combination of treatments in order to achieve weight-loss should it be proven to have a role in the management of endometrial cancer. This study demonstrates a need for patient education regarding the strong relationship between obesity and endometrial cancer risk. Patients are willing to consider weight loss interventions if they were proven to be as safe and effective as pelvic surgery in the management of endometrial cancer.
肥胖是子宫内膜癌最大的风险因素。患者往往对这一风险认识不足。子宫内膜癌管理中体重减轻的证据正在出现。这是一项基于问卷调查的研究,调查了子宫内膜癌合并肥胖患者对肥胖作为癌症风险因素的看法和态度,以及他们参与减肥干预作为子宫内膜癌替代治疗的意愿。这项调查在爱尔兰的一个妇科肿瘤门诊进行。共完成了45/50份(90%)问卷。大多数被调查患者(86.7%;39/45)同意肥胖是一种疾病。略超过一半的队列(53.3%;24/45)认为肥胖会导致癌症。超过三分之一,39.9%(18/45)不同意或强烈不同意肥胖是子宫内膜癌的风险因素,而35.5%(16/45)同意或强烈同意。三分之二(66.6%;30/45)知道通过代谢手术可以减轻最多的体重。超过四分之三(82.1%;37/45)的被调查患者愿意接受联合治疗以实现体重减轻,前提是证明其在子宫内膜癌管理中发挥作用。这项研究表明需要对患者进行关于肥胖与子宫内膜癌风险之间紧密关系的教育。如果被证明在子宫内膜癌管理中与盆腔手术一样安全有效,患者愿意考虑减肥干预。