绵羊中血红蛋白A向血红蛋白C转换的动力学及血浆促红细胞生成素水平

Kinetics of the Hb A to Hb C switch and erythropoietin plasma levels in sheep.

作者信息

Vestri R, Crema A, Testa A, Lostia O

机构信息

Istituto di Fisiologia Umana, Universita Cattolica S. Cuore, Rome, Italy.

出版信息

Anim Genet. 1988;19(3):257-66. doi: 10.1111/j.1365-2052.1988.tb00814.x.

DOI:10.1111/j.1365-2052.1988.tb00814.x

PMID:3207219

Abstract

The induction of Hb A (alpha 2 beta A2) and Hb C (alpha 2 beta C2) synthesis in three adult sheep has been sequentially analysed, in relation to the reduction of the haematocrit (Ht) and to the changes of erythropoietin (Epo) concentration in plasma. Hb A production is detected in peripheral reticulocytes when the Ht approaches 70% of its initial value in correspondence with the first rise of EPO plasma level, whereas HB C synthesis appears when the Ht is further reduced to about 50%, at an Epo concentration two to three times higher. The assumption that the cell committed to HB C synthesis is close to the erythroid colony-forming unit (CFU-e) progenitor is also discussed.

摘要

对三只成年绵羊中血红蛋白A（α2βA2）和血红蛋白C（α2βC2）合成的诱导过程进行了顺序分析，分析内容涉及血细胞比容（Ht）的降低以及血浆中促红细胞生成素（Epo）浓度的变化。当Ht接近其初始值的70%时，外周网织红细胞中检测到血红蛋白A的产生，此时血浆EPO水平首次升高；而当Ht进一步降至约50%，且Epo浓度高出两到三倍时，血红蛋白C的合成开始出现。文中还讨论了致力于血红蛋白C合成的细胞接近红系集落形成单位（CFU-e）祖细胞的假设。