Trinity College, Hartford, CT, USA.
Adv Exp Med Biol. 2020;1227:29-49. doi: 10.1007/978-3-030-36422-9_3.
Cellular development can be controlled by communication between adjacent cells mediated by the highly conserved Notch signaling system. A cell expressing the Notch receptor on one cell can be activated in trans by ligands on an adjacent cell leading to alteration of transcription and cellular fate. Ligands also have the ability to inhibit Notch signaling, and this can be accomplished when both receptor and ligands are coexpressed in cis on the same cell. The manner in which cis-inhibition is accomplished is not entirely clear but it is known to involve several different protein domains of the ligands and the receptor. Some of the protein domains involved in trans-activation are also used for cis-inhibition, but some are used uniquely for each process. In this work, the involvement of various ligand regions and the receptor are discussed in relation to their contributions to Notch signaling.
细胞的发育可以通过相邻细胞之间的通讯来控制，这种通讯是由高度保守的 Notch 信号系统介导的。一个细胞在自身表达 Notch 受体的情况下，可以被相邻细胞上的配体在转位激活，从而导致转录和细胞命运的改变。配体也有抑制 Notch 信号的能力，当受体和配体在同一细胞内顺式共表达时，就可以实现这种抑制。顺式抑制的实现方式尚不完全清楚，但已知它涉及配体和受体的几个不同的蛋白结构域。一些参与转位激活的蛋白结构域也用于顺式抑制，但有些则专门用于每个过程。在这项工作中，讨论了各种配体区域和受体与 Notch 信号转导的关系。
