Di Santo Meztler G Paula, Glesmann Laura A, Esteban M Esther, Del Palacio Santiago, Méndez Marta G, Catanesi Cecilia I
Laboratorio de Diversidad Genética, Instituto Multidisciplinario de Biología Celular, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires - Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas, La Plata, Argentina,
Laboratorio de Diversidad Genética, Instituto Multidisciplinario de Biología Celular, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires - Universidad Nacional de La Plata - Consejo Nacional de Investigaciones Científicas y Técnicas, La Plata, Argentina.
Hum Biol. 2019 Feb 17;91(1):9-20. doi: 10.13110/humanbiology.91.1.02.
In northeast Argentina, different Amerindian communities share territory and history with settlers, mainly Europeans. Due to miscegenation, the current Argentinean population has a particular structure that can be described through X chromosome variation. The objectives of this study were to describe the variation of 10 X-chromosome short tandem repeats (X-STRs) in urban populations of the Argentinean regions known as Gran Chaco and Mesopotamia, report the forensic parameters of these STRs, and estimate the European and indigenous genetic components in these regions. Population and forensic parameters were estimated for 419 individuals from the analyzed populations, including two indigenous groups, Wichí and Mocoví, previously reported. Population structure was estimated through and distances and analysis of molecular variance. The indigenous American and European components were assessed with STRUCTURE. X-STRs showed a high level of genetic variability in urban and indigenous populations. Indigenous people of the Gran Chaco region showed significant differentiation from the urban samples ( = 5.5%) and among themselves ( = 5.3%). Genetic differentiation among urban groups was almost negligible, except that the population from Misión Nueva Pompeya differed from the rest of the city populations. Forensic parameters indicate that these X-STRs are useful as a complement to paternity tests. The set of 10 STRs could be a good tool for examining population differences.
在阿根廷东北部，不同的美洲印第安社区与定居者（主要是欧洲人）共享领土和历史。由于混血，目前的阿根廷人口具有一种特殊的结构，可通过X染色体变异来描述。本研究的目的是描述阿根廷大查科和米西奥内斯地区城市人口中10个X染色体短串联重复序列（X-STRs）的变异情况，报告这些STRs的法医参数，并估计这些地区的欧洲和本土遗传成分。对来自分析人群的419个人进行了群体和法医参数估计，包括之前报道的两个本土群体，威奇族和莫科维族。通过遗传距离和分子方差分析估计群体结构。利用STRUCTURE软件评估美洲原住民和欧洲成分。X-STRs在城市和本土人群中表现出高度的遗传变异性。大查科地区的本土居民与城市样本存在显著差异（FST = 5.5%），且他们自身之间也存在差异（FST = 5.3%）。城市群体之间的遗传分化几乎可以忽略不计，除了新庞贝亚传教区的人群与其他城市人群不同。法医参数表明，这些X-STRs可作为亲子鉴定的补充手段。这组10个STRs可能是检验群体差异的良好工具。
