Xu H M, Wang X
Department of Gastrointestinal Oncology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Feb 25;23(2):109-114. doi: 10.3760/cma.j.issn.1671-0274.2020.02.003.
As early as in the 1960s, China has begun to conduct exploratory clinical researches on gastric cancer. In the past 10 years, the research projects have increased significantly. Among them, the minimally invasive surgery represented by laparoscopy (CLASS Trial), the hot spot of the esophagogastric junction cancer (5010 Trial), the perioperative adjuvant treatment of advanced gastric cancer (CGOG1001 and RESOLVE Trials), the conversion treatment of late gastric cancer (DRAGON Trial) and high quality clinical research such as real-world research based on large database have made great progress. But there are still many deficiencies, such as few multi-center prospective research, limited research return, and the quality and innovation of scientific research data need to be further improved. However, it should also be noted that the clinical researches of gastric cancer in China have greater advantages and development space. The characteristics of large population base, rich cases and large proportion of advanced gastric cancer are conducive to real-world research. In the future, we should follow the international frontier and combine with national conditions to deepen clinical research, so that more "Chinese elements" can be introduced into the international guidelines for gastric cancer, and promote the overall level of diagnosis and treatment of gastric cancer in China.
早在20世纪60年代，中国就已开始对胃癌进行探索性临床研究。在过去十年中，研究项目显著增加。其中，以腹腔镜手术为代表的微创手术（CLASS试验）、食管胃交界癌热点研究（5010试验）、进展期胃癌围手术期辅助治疗（CGOG1001和RESOLVE试验）、晚期胃癌转化治疗（DRAGON试验）以及基于大数据库的真实世界研究等高质量临床研究都取得了很大进展。但仍存在诸多不足，如多中心前瞻性研究较少、研究回报有限，科研数据的质量和创新性有待进一步提高。然而，也应注意到，中国胃癌临床研究具有较大优势和发展空间。人口基数大、病例丰富、进展期胃癌比例高的特点有利于开展真实世界研究。未来，应紧跟国际前沿并结合国情深化临床研究，使更多“中国元素”纳入国际胃癌诊疗指南，推动中国胃癌诊疗整体水平提升。
