Freshage Research Group-Dept. Physiology-University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.
Pharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.
Nutrients. 2020 Feb 14;12(2):486. doi: 10.3390/nu12020486.
We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and and compare them with calorie restriction.
Whole transcriptomic analysis was performed in the brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. Longevity and vitality were tested in .
The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and different from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to aging, were the most affected. Furthermore, a functional analysis in was used. We found that feeding the micronutrient blend increased longevity as well as vitality.
We describe a micronutrient supplement that causes similar changes (transcriptomic and promoting longevity and vitality) as a calorie restriction in mice and , respectively, but further studies are required to confirm these effects in humans.
我们之前描述了一种新型的微量营养素混合物，它的作用类似于假定的热量限制模拟物。本文的目的是分析我们的微量营养素混合物在小鼠中的有益作用，并将其与热量限制进行比较。
在三组小鼠的大脑皮层、骨骼肌和心脏中进行全转录组分析：老年对照组（30 个月）、老年+热量限制组和老年+新型微量营养素混合物组。在 中测试了寿命和活力。
微量营养素混合物引起的转录组变化方式与热量限制组相似，而与对照组不同。亚组分析显示，核激素受体、蛋白酶体复合物和血管紧张素原基因，这些基因都与衰老直接相关，受影响最大。此外，在 中进行了功能分析。我们发现，给 喂养微量营养素混合物可以提高寿命和活力。
我们描述了一种微量营养素补充剂，它在小鼠中引起与热量限制相似的变化（转录组和促进寿命和活力），分别为，但需要进一步的研究来证实这些在人类中的作用。
