Gwinnutt C L, Meakin G
Department of Anaesthesia, Royal Manchester Children's Hospital, Pendlebury.
Br J Anaesth. 1988 Nov;61(5):547-50. doi: 10.1093/bja/61.5.547.
The post-tetanic count was investigated as a method of monitoring intense neuromuscular blockade in children. One of five myoneural blockers (atracurium, vecuronium, pancuronium, tubocurarine or alcuronium) was given to groups of six children during nitrous oxide-oxygen-halothane anaesthesia. During recovery, the first post-tetanic response always preceded the first train-of-four response. The interval between the appearance of the first post-tetanic response and the first train-of-four response was typically 5-10 min for the intermediate-acting agents vecuronium and atracurium, and 20-30 min for the long-acting agents pancuronium, alcuronium and tubocurarine. A post-tetanic count of 6 with alcuronium and tubocurarine, or 7 with vecuronium, atracurium and pancuronium indicated that recovery of the first train-of-four response was imminent.
对强直刺激后计数作为监测儿童深度神经肌肉阻滞的一种方法进行了研究。在氧化亚氮-氧气-氟烷麻醉期间，将五种肌松药（阿曲库铵、维库溴铵、泮库溴铵、筒箭毒碱或阿库氯铵）之一给予每组六名儿童。在恢复过程中，首次强直刺激后反应总是先于首次四个成串刺激反应出现。对于中效肌松药维库溴铵和阿曲库铵，首次强直刺激后反应与首次四个成串刺激反应出现的间隔通常为5-10分钟，而对于长效肌松药泮库溴铵、阿库氯铵和筒箭毒碱，该间隔为20-30分钟。阿库氯铵和筒箭毒碱的强直刺激后计数为6，或维库溴铵、阿曲库铵和泮库溴铵的强直刺激后计数为7时，表明首次四个成串刺激反应即将恢复。
