Chemistry Department, Duke University, Durham, NC 27708, USA.
Molecules. 2020 Feb 15;25(4):862. doi: 10.3390/molecules25040862.
We compare steps observed during the fibrillogenesis of myofibrils with the sequence of steps predictable by a recent analysis of the structurization and functioning of striated muscles. The predicted assembly steps are based solely on fundamental equilibrium processes, particularly supramolecular interactions and liquid crystalline alignment of the rigid thick and thin filaments hosted within the sarcomer. Satisfactory agreement is obtained between several of the observed and the predicted fibrillogenesis steps. In several cases, however, the actual steps appear to be more complex than expected, evidencing the occurrence of transport and kinetic pathways that may assist the attainment of the equilibrium structure. The memory of the order of a precursor mesophase is imprinted during the remodeling of the surfaces at which the two sets of filaments are anchored. The relevance of the present analysis to the functioning of the myofibril is considered.
我们将肌原纤维纤颤形成过程中的观察步骤与最近对横纹肌结构和功能的分析中可预测的步骤序列进行了比较。预测的组装步骤仅基于基本的平衡过程，特别是在肌节内的刚性粗、细肌丝的超分子相互作用和液晶排列。观察到的和预测的纤颤形成步骤之间有几个得到了令人满意的一致。然而，在某些情况下，实际步骤似乎比预期的更复杂，表明存在可能有助于达到平衡结构的运输和动力学途径。在两种纤维锚定的表面进行重塑时，会留下前中间相有序的记忆。本文分析对肌原纤维功能的相关性也进行了考虑。
