The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Sandra and Edward Meyer Cancer Center, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Immunity. 2020 Feb 18;52(2):212-214. doi: 10.1016/j.immuni.2020.01.015.
Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R.
通过 MerTK 受体吞噬凋亡细胞对于免疫耐受很重要。在本期《免疫》中，Zhou 等人报道阻断 MerTK 介导的吞噬作用通过一种机制调动了抗肿瘤免疫，该机制涉及通过 ATP 激活的 P2X7R 通道将肿瘤衍生的 cGAMP 转运到巨噬细胞中。
