Signorelli Salvatore Santo, Vanella Luca, Abraham Nader G, Scuto Salvatore, Marino Elisa, Rocic Petra
Department of Clinical and Experimental Medicine, University of Catania, University Hospital 'G. Rodolico', Catania, 95124, Italy.
Department of Drug Science, University of Catania, Catania, Italy.
Ther Adv Chronic Dis. 2020 Feb 5;11:2040622319894466. doi: 10.1177/2040622319894466. eCollection 2020.
Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.
外周动脉疾病（PAD）在较为发达国家主要影响65岁以上的人群。在这种慢性动脉疾病的病理生理过程中，血流动力学、炎症和氧化机制相互作用。我们讨论了与外周动脉慢性缺血相关的血流动力学、肌肉组织和氧化应激（OxS）情况。本综述总结了评估代谢和氧化标志物的结果，以及对抗OxS的治疗方法。总之，我们认为应该突出不同途径以发现治疗PAD患者的新药。
