Nix Colette E, Lee Justine A, Wismer Tina
Animal Emergency and Referral Center of Minnesota, Oakdale, MN.
ASPCA Animal Poison Control Center, Urbana, IL.
J Vet Emerg Crit Care (San Antonio). 2020 May;30(3):302-307. doi: 10.1111/vec.12935. Epub 2020 Feb 19.
To describe a case series of systemic lime sulfur toxicosis secondary to topical administration in 2 cats.
Two cats from the same household that were being previously treated for Microsporum canis were presented following topical administration of an incorrectly diluted lime sulfur dip. A 30% solution was used rather than the recommended 3% solution, resulting in a 10-fold concentration overdose. The cats presented to the emergency service 1 hour after dermal application of the lime sulfur product at home. The first cat, a 2-year-old female, intact Cornish Rex, had severe hypotension, bradycardia, and hypothermia. Chemical burns were also present on the ventrum and paws. Clinicopathological data revealed profound acid-base disturbances, hypercalcemia, hyperphosphatemia, and azotemia. After aggressive fluid resuscitation, electrolyte supplementation, and treatment, the patient was stabilized and discharged after 5 days of hospitalization; full recovery was later reported. The second littermate, also a 2-year-old female, intact Cornish Rex, presented the following day with similar clinical signs, physical examination findings, and clinicopathological findings. After supportive care and 2 days of hospitalization, the patient was also discharged and reported to fully recover.
This case series is the first to report systemic toxicosis secondary to dermal exposure of lime sulfur. As lime sulfur is commonly used in veterinary medicine for the treatment of ectoparasites, veterinary professionals should be aware of the significant signs of poisoning that can be seen as a result of iatrogenic dosing errors by pet owners or veterinary professionals.
描述2只猫局部应用石硫合剂后发生全身中毒的病例系列。
来自同一家庭的2只猫,此前正在接受犬小孢子菌感染的治疗,在局部应用了稀释错误的石硫合剂浸浴后前来就诊。使用的是30%的溶液而非推荐的3%溶液,导致浓度过量10倍。猫在家中皮肤应用石硫合剂产品1小时后被送到急诊室。第一只猫是一只2岁的未绝育雌性康沃尔卷毛猫,出现严重低血压、心动过缓和体温过低。腹部和爪子也有化学灼伤。临床病理数据显示有严重的酸碱紊乱、高钙血症、高磷血症和氮质血症。经过积极的液体复苏、补充电解质和治疗,患者在住院5天后病情稳定并出院;后来报告已完全康复。第二只同窝猫,也是一只2岁的未绝育雌性康沃尔卷毛猫,第二天出现了类似的临床症状、体格检查结果和临床病理结果。经过支持治疗和住院2天后,该患者也出院了,并报告已完全康复。
该病例系列是首次报告因皮肤接触石硫合剂继发全身中毒。由于石硫合剂在兽医学中常用于治疗体外寄生虫,兽医专业人员应意识到因宠物主人或兽医专业人员医源性给药错误可能出现的中毒显著体征。