Dönmez Yunus Emre, Özcan Özlem, Bilgiç Ayhan, Miniksar Dilşad Yıldız
Department of Child and Adolescent Psychiatry, Malatya Training and Research Hospital, Malatya, Turkey.
Department of Child and Adolescent Psychiatry, İnönü University Faculty of Medicine, Malatya, Turkey.
Turk J Pediatr. 2019;61(2):193-199. doi: 10.24953/turkjped.2019.02.007.
Dönmez YE, Özcan Ö, Bilgiç A, Miniksar DY. The relationship between prenatal testosterone and developmental stuttering in boys. Turk J Pediatr 2019; 61: 193-199. Stuttering is a multi-factorial speech disorder characterized by various dysfluencies in the beginning and/or smooth flow of speech. Its incidence is about 1% in the general population, with 80% of stuttering cases seen in children aged three to eight years. The etiology of developmental stuttering has not been precisely explained. Several researchers report that neurological factors, especially atypical lateralization of the speech and language processes, play an important role in the etiology of stuttering. Various hypotheses suggest that prenatal testosterone causes atypical hemispheric lateralization. The aim of this study was to investigate the role of prenatal testosterone in the etiology of developmental stuttering by the use of the ratio of secondand fourth-digit lengths (2D:4D). Totally 133 boys (49 boys who stutter and 84 boys who do not stutter) were included in the study. The age range of children participating in the study was determined as 2-12 years. In the comparative evaluation conducted between the stuttering group and the control group in terms of their right 2D:4D and left 2D:4D ratios, it was found that the left 2D:4D ratio of the patients was significantly higher than that of the control group. We are of the opinion that prenatal testosterone may play a role in the etiology of developmental stuttering. The present study is the first study in the literature to reveal a relationship between prenatal testosterone and developmental stuttering.
多恩梅兹·耶尔、厄兹坎·厄、比尔吉奇·A、米尼克斯尔·DY。男孩产前睾酮与发育性口吃之间的关系。《土耳其儿科学杂志》2019年；61: 193 - 199。口吃是一种多因素言语障碍，其特征是在言语起始和/或流畅表达过程中出现各种不流畅。在普通人群中的发病率约为1%，80%的口吃病例见于3至8岁的儿童。发育性口吃的病因尚未得到确切解释。几位研究人员报告说，神经因素，尤其是言语和语言过程的非典型侧化，在口吃的病因中起重要作用。各种假说表明，产前睾酮会导致非典型的半球侧化。本研究的目的是通过使用食指与无名指长度之比（2D:4D）来研究产前睾酮在发育性口吃病因中的作用。共有133名男孩（49名口吃男孩和84名非口吃男孩）纳入本研究。参与研究的儿童年龄范围确定为2至12岁。在口吃组和对照组之间就其右手2D:4D和左手2D:4D比值进行的比较评估中，发现患者的左手2D:4D比值显著高于对照组。我们认为产前睾酮可能在发育性口吃的病因中起作用。本研究是文献中第一项揭示产前睾酮与发育性口吃之间关系的研究。
