Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China.
Foodborne Pathog Dis. 2020 Oct;17(10):597-601. doi: 10.1089/fpd.2019.2769. Epub 2020 Feb 20.
An strain isolated from the feces of swine at a pork slaughterhouse in Henan province China was found to possess two colistin-resistance genes, and , plus 16 additional resistance genes. Genes and were identified on IncHI2 and IncX1 type plasmids, respectively. Transconjugants (containing , &) were obtained that were 64- and 512-fold higher than the minimum inhibitory concentration of colistin on the recipient bacteria ( C600), respectively. The IncX1 plasmid containing displayed a very specific structure compared with previous . Variable and stable regions were similar across different plasmids, multiple insertion sequences and transposases.
从中国河南省一家猪肉屠宰场的猪粪便中分离到一株 菌株，该菌株携带两种黏菌素耐药基因 和 ，以及另外 16 种耐药基因。基因 和 分别位于 IncHI2 和 IncX1 型质粒上。获得了含有 、和 的转染子（），它们对受体菌（C600）的最小抑菌浓度（MIC）的耐药性分别提高了 64 倍和 512 倍。与之前的 相比，携带 的 IncX1 质粒表现出非常特殊的结构。不同质粒之间的可变区和稳定区相似，存在多个插入序列和转座酶。
