Pereira M P, Hoffmann V, Weisshaar E, Wallengren J, Halvorsen J A, Garcovich S, Misery L, Brenaut E, Savk E, Potekaev N, Lvov A, Bobko S, Szepietowski J C, Reich A, Bozek A, Legat F J, Metz M, Streit M, Serra-Baldrich E, Gonçalo M, Storck M, Greiwe I, Nau T, Steinke S, Dugas M, Ständer S, Zeidler C
Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
Occupational Medicine, Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
J Eur Acad Dermatol Venereol. 2020 Oct;34(10):2373-2383. doi: 10.1111/jdv.16309. Epub 2020 May 12.
Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking.
Aim of this pan-European multicentre cross-sectional study was to establish the clinical profile of CNPG, including its associated burden.
Fifteen centres from 12 European countries recruited CNPG patients presenting at the centre or using the centres' own databases. Patients were asked to complete a questionnaire in paper or electronic format. Demography, current co-morbidities, underlying disease, itch intensity, additional sensory symptoms, quality of life, highest burden and emotional experience of itch were assessed.
A total of 509 patients (210 male, median age: 64 years [52; 72]) were enrolled. Of these, 406 reported itch and CNPG lesions in the previous 7 days and qualified to complete the whole questionnaire. We recorded moderate to severe worst itch intensity scores in the previous 24 h. Scores were higher in patients with lower educational levels and those coming from Eastern or Southern Europe. Most patients experience itch often or always (71%) and report that their everyday life is negatively affected (53%). Itch intensity was considered to be the most burdensome aspect of the disease by 49% of the patients, followed by the visibility of skin lesions (21%) and bleeding of lesions (21%). The majority of patients was unaware of an underlying condition contributing to CNPG (64%), while psychiatric diseases were the conditions most often mentioned in association with CNPG (19%).
This multicentre cross-sectional study shows that itch is the dominant symptom in CNPG and reveals that the profile of the disease is similar throughout Europe.
慢性结节性痒疹（CNPG）是一种以慢性瘙痒、长期搔抓行为和瘙痒性结节为特征的疾病。目前仍缺乏对该疾病的全面了解，尤其是其临床特征和对生活质量的影响。
这项泛欧洲多中心横断面研究的目的是确定CNPG的临床特征，包括其相关负担。
来自12个欧洲国家的15个中心招募了在中心就诊或使用中心自身数据库的CNPG患者。患者被要求以纸质或电子形式完成一份问卷。评估了人口统计学、当前合并症、基础疾病、瘙痒强度、其他感觉症状、生活质量、最高负担以及瘙痒的情感体验。
共纳入509例患者（男性210例，中位年龄：64岁[52；72]）。其中，406例在前7天报告有瘙痒和CNPG皮损，有资格完成整个问卷。我们记录了患者在前24小时内中度至重度的最严重瘙痒强度评分。教育程度较低以及来自东欧或南欧的患者评分更高。大多数患者经常或总是感到瘙痒（71%），并报告他们的日常生活受到负面影响（53%）。49%的患者认为瘙痒强度是该疾病最沉重的方面，其次是皮肤病变的可见性（21%）和病变出血（21%）。大多数患者不知道有导致CNPG的基础疾病（64%），而精神疾病是最常被提及与CNPG相关的疾病（19%）。
这项多中心横断面研究表明，瘙痒是CNPG的主要症状，并揭示了该疾病在欧洲各地的特征相似。
