刚体处理中刚性弯杆大分子和半柔性断杆的输运性质。肌球蛋白杆柔韧性分析。
Transport properties of rigid bent-rod macromolecules and of semiflexible broken rods in the rigid-body treatment. Analysis of the flexibility of myosin rod.
作者信息
Iniesta A, Díaz F G, García de la Torre J
机构信息
Departamento de Quimica Fisica, Facultad de Ciencias Quimicas y Matematicas, Universidad de Murcia, Spain.
出版信息
Biophys J. 1988 Aug;54(2):269-75. doi: 10.1016/S0006-3495(88)82956-4.
The translational diffusion coefficients, rotational relaxation times and intrinsic viscosities of rigid bent rods, composed by two rodlike arms joined rigidly at an angle alpha, have been evaluated for varying conformation using the latest advances in hydrodynamic theory. We have considered semiflexible rods in which the joint is an elastic hinge or swivel, with a potential V(alpha) = 1/2Q alpha 2 with constant Q. Accepting the rigid-body treatment, we calculate properties of broken rods by averaging alpha-dependent values for rigid rods. The results are finally used to interpret literature values of the properties of myosin rod. Q is regarded as an adjustable parameter, and the value fitted is such that the average bending angle of myosin rod is approximately 60 degrees.
由两个呈角度α刚性连接的棒状臂组成的刚性弯曲棒的平动扩散系数、转动弛豫时间和特性粘度，已利用流体动力学理论的最新进展针对不同构象进行了评估。我们考虑了半柔性棒，其中接头是一个弹性铰链或旋转接头，具有势能V(α)=1/2Qα²，Q为常数。接受刚体处理后，我们通过对刚性棒的α相关值求平均来计算断棒的性质。结果最终用于解释肌球蛋白棒性质的文献值。Q被视为一个可调参数，拟合得到的值使得肌球蛋白棒的平均弯曲角度约为60度。
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