Vishnevetsiĭ F E, Iushchenko A A, Anokhina V V
Biull Eksp Biol Med. 1988 Dec;106(12):737-41.
Leproma pieces obtained from leprosy patients and M. leprae-infected animals were cultivated by the method of primary explantation. It is noted that the development of a monolayer from macrophages overloaded with M. leprae is a characteristic common to the lepromas of various origin. Antileprosy activity of the drugs under study was assessed by the rate of decrease in mycobacterial load of macrophages. Species features of cultivated lepromas from man, nine-banded armadillo and mouse are characterised. While cultivating lepromas from leprosy patients the peculiarities of tissue culture organization are found out representing immune status and prognosis of specific therapy.
采用原代外植体培养法培养从麻风病人和感染麻风分枝杆菌的动物身上获取的麻风瘤组织块。值得注意的是，由负载大量麻风分枝杆菌的巨噬细胞形成单层是各种来源麻风瘤的共同特征。通过巨噬细胞中分枝杆菌载量的下降速率评估所研究药物的抗麻风活性。对来自人、九带犰狳和小鼠的培养麻风瘤的物种特征进行了描述。在培养麻风病人的麻风瘤时，发现了组织培养组织的特点，这些特点反映了免疫状态和特异性治疗的预后。
