Saebye Casper, Amidi Ali, Keller Johnny, Andersen Henning, Baad-Hansen Thomas
Department of Orthopedic Surgery, Sarcoma Centre of Aarhus University Hospital, Aarhus DK-8200, Denmark.
Department of Experimental Clinical Oncology, Sarcoma Centre of Aarhus University Hospital, Aarhus DK-8200, Denmark.
Cancers (Basel). 2020 Feb 17;12(2):463. doi: 10.3390/cancers12020463.
Soft tissue sarcoma (STS) patients undergoing surgery may experience reduced functional outcome (FO) and quality of life (QoL) compared to the general population. The aim of this study was to evaluate the development of FO and QoL in patients with STS in the extremities within the first year after first-time limb-sparing surgery. Twenty-nine out of 40 eligible patients were included in the present study. QoL and FO were evaluated by questionnaires while FO was also evaluated by objective tests. Patients were assessed before surgery and at fixed time points within the first year after surgery. Patients with STS in the extremities had an average strength of 82.34% (95% CI: 68.57-96.11) of the expected strength at one year post surgery. Multivariate, repeated ANOVA showed statistically significant reductions in strength in the disease-affected extremity when compared with the healthy side after surgery. Multivariate, repeated ANOVA showed a statistically significant improvement in FO and QoL within the first year post surgery. Limb-sparing surgery for STS significantly reduced strength in the disease-affected extremity and generally reduced FO and QoL in the first months after surgery. Improvements were observed for FO and QoL at one year after surgery.
与普通人群相比，接受手术的软组织肉瘤（STS）患者可能会出现功能结局（FO）和生活质量（QoL）下降的情况。本研究的目的是评估首次保肢手术后一年内四肢STS患者的FO和QoL的变化情况。40名符合条件的患者中有29名被纳入本研究。通过问卷评估QoL和FO，同时也通过客观测试评估FO。在手术前以及术后第一年的固定时间点对患者进行评估。四肢STS患者在术后一年的平均力量为预期力量的82.34%（95%置信区间：68.57 - 96.11）。多变量重复方差分析显示，与术后健康侧相比，患病肢体的力量在统计学上有显著下降。多变量重复方差分析显示，术后第一年FO和QoL有统计学上的显著改善。STS保肢手术显著降低了患病肢体的力量，并且在术后最初几个月通常会降低FO和QoL。术后一年观察到FO和QoL有所改善。
