Faculty of Chemistry, Adam Mickiewicz University, 61-614 Poznan, Poland.
Center for Advanced Technology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Molecules. 2020 Feb 17;25(4):877. doi: 10.3390/molecules25040877.
Laser flash photolysis and high-resolution mass spectrometry were used to investigate the mechanism of one-electron oxidation of two -alkylglutathiones using 3-carboxybenzophenone (3CB) as a photosensitizer. This report indicates an unexpected reaction pathway of the α-aminoalkyl radical cation (αN) derived from the oxidation of -alkylglutathiones. Instead of a common hydrolysis reaction of αN reported earlier for methionine and other sulfur-containing aminoacids and peptides, an intramolecular ring-closure reaction was found for -alkylglutathiones.
激光闪光光解和高分辨率质谱联用技术被用于研究使用 3-羧基二苯甲酮（3CB）作为光敏剂的二烷基谷胱甘肽的单电子氧化反应机制。该报告指出了来自于二烷基谷胱甘肽氧化的α-氨烷基自由基阳离子（αN）的一个意想不到的反应途径。与之前报道的甲硫氨酸和其他含硫氨基酸和肽的αN的常见水解反应不同，对于二烷基谷胱甘肽发现了分子内环合反应。
