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Tofacitinib in refractory adult-onset Still's disease: 14 cases from a single centre in China.

作者信息

Hu Qiongyi, Wang Mengyan, Jia Jinchao, Teng Jialin, Chi Huihui, Liu Tingting, Liu Hong-Lei, Cheng Xiaobing, Ye Junna, Su Yutong, Sun Yue, Zhou Zhuochao, Wan Liyan, Wang Zhihong, Wang Fan, Shi Hui, Yang Chengde

机构信息

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

出版信息

Ann Rheum Dis. 2020 Jun;79(6):842-844. doi: 10.1136/annrheumdis-2019-216699. Epub 2020 Feb 20.

DOI:10.1136/annrheumdis-2019-216699
PMID:32079571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7286046/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1241/7286046/30cb4c723999/annrheumdis-2019-216699f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1241/7286046/30cb4c723999/annrheumdis-2019-216699f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1241/7286046/30cb4c723999/annrheumdis-2019-216699f01.jpg

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[Successful treatment of adult Still's disease with tofacitinib in a HIV-2 positive female patient].[托法替布成功治疗一名HIV-2阳性成年女性患者的成人斯蒂尔病]
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JAK inhibitors in difficult-to-treat adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis.JAK抑制剂在难治性成人斯蒂尔病和全身型幼年特发性关节炎中的应用
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Treatment of Hypereosinophilic Syndrome with Cutaneous Involvement with the JAK Inhibitors Tofacitinib and Ruxolitinib.使用JAK抑制剂托法替布和芦可替尼治疗伴有皮肤受累的高嗜酸性粒细胞综合征。
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Clin Rheumatol. 2025 May 8. doi: 10.1007/s10067-025-07465-1.
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Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult-Onset Still's Disease.

本文引用的文献

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Application of MS score in macrophage activation syndrome patients associated with adult onset Still's disease.MS评分在成人斯蒂尔病相关巨噬细胞活化综合征患者中的应用。
Ann Rheum Dis. 2021 Sep;80(9):e145. doi: 10.1136/annrheumdis-2019-216286. Epub 2019 Oct 14.
2
JAK inhibitors for the treatment of autoimmune and inflammatory diseases.JAK 抑制剂治疗自身免疫性和炎症性疾病。
Autoimmun Rev. 2019 Nov;18(11):102390. doi: 10.1016/j.autrev.2019.102390. Epub 2019 Sep 11.
3
Tofacitinib Treatment of Refractory Systemic Juvenile Idiopathic Arthritis.
成人斯蒂尔病患者的遗传图谱及新型炎症生物标志物特征分析
Arthritis Rheumatol. 2025 May;77(5):582-595. doi: 10.1002/art.43054. Epub 2024 Dec 16.
4
A Case Report of JAK Inhibitors Therapy for Adult-Onset Still's Disease with Persistent Pruritic Lesions.成人Still 病伴持续瘙痒皮损采用 JAK 抑制剂治疗 1 例报告
Drugs R D. 2024 Sep;24(3):391-394. doi: 10.1007/s40268-024-00487-1. Epub 2024 Sep 18.
5
Diagnosing and Treating Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease as Part of the Still's Disease Continuum.将系统性幼年特发性关节炎和成人斯蒂尔病作为斯蒂尔病连续谱的一部分进行诊断和治疗。
Mediterr J Rheumatol. 2024 Mar 30;35(Suppl 1):45-57. doi: 10.31138/mjr.290323.dat. eCollection 2024 Mar.
6
Adult-Onset Still's Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options.成人Still 病（AOSD）：对发病机制、遗传学和新兴治疗选择的理解的进展。
Drugs. 2024 Mar;84(3):257-274. doi: 10.1007/s40265-024-01993-x. Epub 2024 Mar 5.
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Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne.中断化脓性关节炎、坏疽性脓皮病和痤疮综合征中 IFN-γ 依赖性反馈环。
Ann Rheum Dis. 2024 May 15;83(6):787-798. doi: 10.1136/ard-2023-225085.
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Front Pediatr. 2024 Jan 22;11:1336554. doi: 10.3389/fped.2023.1336554. eCollection 2023.
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托法替尼治疗难治性全身型幼年特发性关节炎。
Pediatrics. 2019 May;143(5). doi: 10.1542/peds.2018-2845. Epub 2019 Apr 4.
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Arthritis Res Ther. 2019 Feb 12;21(1):53. doi: 10.1186/s13075-019-1838-6.
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Inflamm Bowel Dis. 2019 Mar 14;25(4):647-660. doi: 10.1093/ibd/izy364.
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Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still's disease.中性粒细胞胞外诱捕网增加激活成年Still 病中的 NLRP3 和炎性巨噬细胞。
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Treatment of refractory adult onset Still's disease with combination anakinra and baricitinib therapy.联合使用阿那白滞素和巴瑞替尼治疗难治性成人斯蒂尔病。
Rheumatology (Oxford). 2019 Apr 1;58(4):736-737. doi: 10.1093/rheumatology/key414.
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Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils.托法替布抑制粒细胞-巨噬细胞集落刺激因子诱导的人中性粒细胞中 NLRP3 炎性体的激活。
Arthritis Res Ther. 2018 Aug 29;20(1):196. doi: 10.1186/s13075-018-1685-x.
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A Pilot Study on Tocilizumab for Treating Refractory Adult-Onset Still's Disease.托珠单抗治疗难治性成人斯蒂尔病的一项初步研究。
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Clinical manifestations but not cytokine profiles differentiate adult-onset Still's disease and sepsis.临床表现而非细胞因子谱可区分成人斯蒂尔病和脓毒症。
J Rheumatol. 2010 Nov;37(11):2369-76. doi: 10.3899/jrheum.100247. Epub 2010 Sep 1.