双环胺对豚鼠回肠中的M1和M2毒蕈碱受体具有鉴别作用。
Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum.
作者信息
Kilbinger H, Stein A
机构信息
Pharmakologisches Institut Universität, Mainz, F.R.G.
出版信息
Br J Pharmacol. 1988 Aug;94(4):1270-4. doi: 10.1111/j.1476-5381.1988.tb11647.x.
Abstract
- The affinity of the antagonist dicyclomine for subtypes of muscarinic receptors has been assessed in the myenteric plexus-longitudinal muscle preparation of the guinea-pig. 2. Dicyclomine had a high affinity (pA2 9.13) for the neuronal M1-receptor whose activation by pilocarpine causes an increase in acetylcholine release. Dicyclomine had a low affinity for both the prejunctional M2-receptor (pA2 7.61) mediating inhibition of the electrically-evoked acetylcholine release and the postjunctional M2-receptor (pA2 7.21). 3. It is concluded that dicyclomine distinguishes between M1- and M2-muscarinic receptors in functional experiments.
摘要
- 已在豚鼠的肠肌丛-纵行肌制备物中评估了拮抗剂双环维林对毒蕈碱受体亚型的亲和力。2. 双环维林对神经元M1受体具有高亲和力（pA2 9.13），毛果芸香碱激活该受体可导致乙酰胆碱释放增加。双环维林对介导电诱发乙酰胆碱释放抑制的节前M2受体（pA2 7.61）和节后M2受体（pA2 7.21）均具有低亲和力。3. 得出的结论是，在功能实验中双环维林可区分M1和M2毒蕈碱受体。
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