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黑色素皮质素信号系统干扰在人免疫缺陷病毒感染者中与某些抗逆转录病毒药物相关的体重增加过多中的潜在作用。

Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV.

机构信息

Department of Infectious Diseases, Hospital de la Santa Creu i Sant Pau, Institut de Recerca del Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Departament de Bioquímica i Biomedicina Molecular and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Spain.

出版信息

Int J Obes (Lond). 2020 Sep;44(9):1970-1973. doi: 10.1038/s41366-020-0551-5. Epub 2020 Feb 20.

DOI:10.1038/s41366-020-0551-5
PMID:32080347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7445112/
Abstract

Exposure to some antiretroviral drugs, especially integrase strand transfer inhibitors (INsTI)-based combination antiretroviral therapy (cART) has been associated with weight gain in people living with HIV (PLWH) exceeding what would be a "return to health" phenomenon. Notwithstanding the fact that weight gain and obesity are multifactorial, the common epidemiological link in PLWH is INsTI-based cART. Here, we postulate that interference with the melanocortin system (MCS) functioning by INsTI plays an essential role in excess weight gain and obesity in PLWH, similar to disturbances caused by melanocortin receptor (MCR) mutations in the general population and by antipsychotic therapy in psychiatric patients.

摘要

接触某些抗逆转录病毒药物，特别是基于整合酶链转移抑制剂（INSTI）的联合抗逆转录病毒疗法（cART），与艾滋病毒感染者（PLWH）体重增加有关，超过了“恢复健康”的现象。尽管体重增加和肥胖是多因素的，但 PLWH 之间的常见流行病学联系是基于 INSTI 的 cART。在这里，我们假设 INSTI 对黑皮质素系统（MCS）功能的干扰在 PLWH 中体重过度增加和肥胖中起着重要作用，类似于黑皮质素受体（MCR）突变在普通人群中引起的干扰和抗精神病药物治疗在精神科患者中引起的干扰。