Kumamoto E, Shinnick-Gallagher P
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
Brain Res. 1988 Aug 16;458(1):151-6. doi: 10.1016/0006-8993(88)90508-2.
Intracellular recording techniques were used to study the action of an irreversible anticholinesterase, soman, on cholinergic transmission in cat bladder parasympathetic neurons. With soman (0.1-10 microM) treatment, nicotinic depolarizations were increased in amplitude and prolonged in duration, whereas muscarinic hyperpolarizations showed either a depressed amplitude and prolonged duration, or were completely blocked. These data suggest that the final result of soman action is different at nicotinic and muscarinic receptor-channel complexes in parasympathetic neurons.
采用细胞内记录技术研究不可逆性抗胆碱酯酶索曼对猫膀胱副交感神经元胆碱能传递的作用。用索曼（0.1 - 10微摩尔）处理后，烟碱样去极化的幅度增加且持续时间延长，而毒蕈碱样超极化则表现为幅度降低、持续时间延长或完全被阻断。这些数据表明，索曼作用于副交感神经元烟碱样和毒蕈碱样受体 - 通道复合物的最终结果不同。
