Harrell L E, Parsons D S
Department of Neurology, Veterans Administration Medical Center, Birmingham, Alabama.
Brain Res. 1988 Dec 6;474(2):353-8. doi: 10.1016/0006-8993(88)90450-7.
Following cholinergic denervation of the neocortex by nucleus basalis magnocellularis (NBM) lesions, peripheral sympathetic fibers grow into the neocortex. Two experiments were performed to determine the behavioral effects of this neuronal rearrangement. Group I animals underwent training on a standard radial-8-arm maze task, while Group II animals learned a modified version (i.e. 4 arms baited). Following acquisition, NBM lesions were performed. Animals with lesions but without sympathetic ingrowth performed consistently better in both behavioral paradigms, than animals with NBM lesions and sympathetic ingrowth. These studies suggest that cortical sympathetic ingrowth can alter behavior and is detrimental to the learning of a spatial memory paradigm.
在通过基底大细胞核（NBM）损伤使新皮质发生胆碱能去神经支配后，外周交感神经纤维长入新皮质。进行了两项实验以确定这种神经元重排的行为效应。第一组动物在标准的放射状八臂迷宫任务上接受训练，而第二组动物学习的是一个修改版本（即四个臂放置诱饵）。在习得后，进行NBM损伤。有损伤但无交感神经长入的动物在两种行为范式中表现始终优于有NBM损伤且有交感神经长入的动物。这些研究表明，皮质交感神经长入可改变行为，并且对空间记忆范式的学习有害。
