Gröhn P
Acta Paediatr Scand. 1977 Mar;66(2):211-7. doi: 10.1111/j.1651-2227.1977.tb07835.x.
Five cases with abnormal sensitivity to respiratory tract infections are described. The cases showed a marked impairment in their cell mediated immunity state. Administration of a chromatographically purified transfer factor component increased the skin test sensitivity to common recall antigens. Interestingly, a similar effect in skin reactivity was observed with repeated skin tests alone, when antigen concentrations, initially high enough to cause a positive reaction, were used. Neither the administration of transfer factor nor skin testing with high antigen concentrations had an effect on blast transformation percentages. The therapy with chromatographically purified transfer factor appeared promising on the clinical condition of the patients.
本文描述了5例对呼吸道感染敏感性异常的病例。这些病例显示出细胞介导免疫状态明显受损。给予经色谱纯化的转移因子成分可提高对常见回忆抗原的皮肤试验敏感性。有趣的是，当使用最初浓度高到足以引起阳性反应的抗原进行单独反复皮肤试验时，也观察到了类似的皮肤反应性变化。给予转移因子和使用高浓度抗原进行皮肤试验均未对母细胞转化百分比产生影响。经色谱纯化的转移因子治疗对患者的临床状况似乎很有前景。
