Suljevic Ismet, Basic Suad, Surkovic Ismana, Turan Maida, Musija Ehlimana
Clinic for Anesthesia and Resuscitation, Clinical Center Sarajevo, Bosnia and Herzegovina.
Public Health institution, Institute for Addiction Diseases of Zenica-Doboj Canton, Zenica, Bosnia and Herzegovina.
Med Arch. 2019 Dec;73(6):404-407. doi: 10.5455/medarh.2019.73.404-407.
Low molecular weight heparin (LMWH) is used as anticoagulant in diseases characterized by possible thrombosis, as well as for thromboprophylaxis in surgery. The administration of LMWH preoperatively and postoperatively allows satisfactory thromboprophylaxis of patients undergoing surgery. Their application can reduce the number of platelets.
To determine what effect Reviparin has on platelet values postoperatively in patients undergoing open cholecystectomy.
The study was conducted at the Clinic for Anesthesia and Resuscitation of the Clinical Center of the University of Sarajevo. A retrospective study was performed that included data analysis for 33 patients undergoing open cholecystectomy over a two-year period. There were 22 male and 11 female patients out of a total of 33 patients. Platelet values from laboratory findings of patient's medical history were monitored for 5 days. The values found were recorded in a table containing the patient's first and last name, gender, age and platelet value. All patients had the same endotracheal anesthesia with Propofol, Fentanyl, and Atracurium supplemented with oxygen and nitric oxide at the appropriate dose. All of the patients received same dose of 0.25ml (1432 IU) Reviparin (Clivarin) from Abbott GmbH & Co.KG, preoperatively and postoperatively. Patients undergoing laparoscopic surgery as well as patients receiving other low-molecular-weight heparin or receiving higher doses of Reviparin were excluded from the study. Statistical analysis was performed using the MedCalc v12.7 statistical package for biomedical research.
An analysis of gender representation in the total sample shows that there was 22 or 66.7% of males while there was 11 or 33.3% of female patients. Analysis of platelet values indicates that there is no statistically significant correlation with gender, but that there is a statistically significant correlation between platelet values between samples, ie. that patients who had higher preoperative values retained more platelet values even during postoperative measurements.
Platelet values do not change significantly postoperatively with the use of prophylactic doses of Reviparin, after an open cholecystectomy.
低分子量肝素（LMWH）在以可能发生血栓形成的疾病中用作抗凝剂，也用于手术中的血栓预防。术前和术后给予LMWH可使接受手术的患者获得满意的血栓预防效果。它们的应用可能会减少血小板数量。
确定瑞肝素对接受开腹胆囊切除术患者术后血小板值的影响。
该研究在萨拉热窝大学临床中心麻醉与复苏诊所进行。进行了一项回顾性研究，包括对两年内33例接受开腹胆囊切除术患者的数据分析。33例患者中，男性22例，女性11例。对患者病史实验室检查结果中的血小板值进行了5天的监测。所发现的值记录在一张包含患者姓名、性别、年龄和血小板值的表格中。所有患者均采用相同的丙泊酚、芬太尼和阿曲库铵气管内麻醉，并补充适当剂量的氧气和一氧化氮。所有患者术前和术后均接受相同剂量的0.25ml（1432 IU）瑞肝素（Clivarin，德国雅培公司生产）。接受腹腔镜手术的患者以及接受其他低分子量肝素或接受更高剂量瑞肝素的患者被排除在研究之外。使用MedCalc v12.7生物医学研究统计软件包进行统计分析。
对总样本中性别分布的分析表明，男性有22例，占66.7%，女性患者有11例，占33.3%。血小板值分析表明，与性别无统计学显著相关性，但样本间血小板值存在统计学显著相关性，即术前值较高的患者即使在术后测量时也保留了更多的血小板值。
开腹胆囊切除术后，使用预防性剂量的瑞肝素后，血小板值术后无明显变化。
