Heinrichs I H, McLean D R
Division of Neurology, University of Alberta, Edmonton, Canada.
Can J Neurol Sci. 1988 Nov;15(4):394-6.
The visual evoked potential (VEP) latency was either abnormally prolonged or absent in the involved eye of 47 patients with optic neuritis. Twenty-two of these patients with known multiple sclerosis (MS), had similar abnormalities to 25 patients with no clinical evidence of MS. Follow-up clinical assessment and VEP were done 10 to 42 (mean 22) months later in 34 patients. In 15 of 34 patients with no VEP from the involved eye during initial examination, 6 returned to normal, 8 had prolonged latencies and 1 still had no response at follow up. Of 19 patients who initially had prolonged latencies in the involved eye, 6 returned to normal, 11 had prolonged latencies and 2 had no response at follow up. The VEP is helpful in confirming the diagnosis of ON. The examination must be performed when the patient is symptomatic or soon thereafter as 35% of our patients with an abnormal initial VEP had a normal VEP at follow up. This normalization was not related to the severity of the initial VEP abnormality.
47例视神经炎患者患眼的视觉诱发电位（VEP）潜伏期异常延长或消失。其中22例已知患有多发性硬化症（MS）的患者，与25例无MS临床证据的患者表现出相似的异常。34例患者在10至42个月（平均22个月）后进行了随访临床评估和VEP检查。在初次检查时患眼VEP未引出的34例患者中，15例在随访时有6例恢复正常，8例潜伏期延长，1例仍无反应。在初次检查时患眼潜伏期延长的19例患者中，随访时有6例恢复正常，11例潜伏期延长，2例无反应。VEP有助于确诊视神经炎。检查必须在患者出现症状时或之后不久进行，因为我们最初VEP异常的患者中有35%在随访时VEP恢复正常。这种恢复正常与最初VEP异常的严重程度无关。
