Cheriyan Abhilash, George Arun Jacob Philip, Devasia Antony, Chandrasingh J
Department of Urology, Christian Medical College and Hospital, Vellore, India.
Arab J Urol. 2019 Sep 25;18(1):41-46. doi: 10.1080/2090598X.2019.1668176. eCollection 2020.
: To determine if the interpretation of urodynamic studies (UDS) in children without a rectal catheter may be similar to multi-channel studies, as UDS in children are challenging and can sometimes be difficult to interpret. : In this retrospective pilot study, 115 paediatric pressure-flow studies were included. A blinded investigator was given two sets of UDS traces. The first set had the vesical trace of all children and the second set had the multi-channel trace. The agreement between the interpretations of both the sets was tested by Cohen's κ, and sensitivity, specificity, and predictive values were expressed with 95% confidence intervals (CIs). The voiding pattern was compared and Pearson's correlation coefficient was used to analyse the pressure at maximum urinary flow (Q). : The most common indications for UDS were neurogenic bladder and posterior urethral valves. The interpretation of compliance and detrusor overactivity by single-channel analysis had a positive predictive value of 92.1% (95% CI 84.7-96.1%) and 89.4% (95% CI 78.3-95.6%), respectively, and a negative predictive value of 100% and 97.1% (95% CI 89.5-99.2%) respectively, in comparison to multi-channel analysis. Children with underactive detrusor were identified reliably by analysing the straining pressure pattern and flow curve. Amongst children who voided, the pressure at Q showed a moderate correlation (Pearson's coefficient = 0.53) between the two groups. : Rectal catheters may be avoided in a carefully selected group of children undergoing UDS who only need filling phase assessment. DO: detrusor overactivity; EBC: expected bladder capacity; P: abdominal pressure; P: detrusor pressure; PUV: posterior urethral valve; (N)(P)PV: (negative) (positive) predictive value; P: vesical pressure; Q: maximum urinary flow rate; UDS: urodynamic studies; UI: urinary incontinence.
为确定在无直肠导管情况下儿童尿动力学研究(UDS)的解读是否可能与多通道研究相似,因为儿童的UDS具有挑战性且有时难以解读。在这项回顾性试点研究中,纳入了115例儿科压力 - 流率研究。一名盲法研究者被给予两组UDS轨迹。第一组有所有儿童的膀胱轨迹,第二组有多通道轨迹。通过科恩κ检验两组解读之间的一致性,敏感性、特异性和预测值以95%置信区间(CI)表示。比较排尿模式,并使用皮尔逊相关系数分析最大尿流率(Q)时的压力。UDS最常见的适应证是神经源性膀胱和后尿道瓣膜。与多通道分析相比,单通道分析对顺应性和逼尿肌过度活动的解读的阳性预测值分别为92.1%(95%CI 84.7 - 96.1%)和89.4%(95%CI 78.3 - 95.6%),阴性预测值分别为100%和97.1%(95%CI 89.5 - 99.2%)。通过分析用力排尿压力模式和流率曲线可可靠地识别逼尿肌活动低下的儿童。在排尿的儿童中,两组之间Q时的压力显示出中等相关性(皮尔逊系数 = 0.53)。在经过精心挑选、仅需要充盈期评估的接受UDS的儿童组中,可避免使用直肠导管。DO:逼尿肌过度活动;EBC:预期膀胱容量;P:腹压;P:逼尿肌压力;PUV:后尿道瓣膜;(N)(P)PV:(阴性)(阳性)预测值;P:膀胱压力;Q:最大尿流率;UDS:尿动力学研究;UI:尿失禁