Yaldız Demet, Acar Arkın, Örs Kaya Şeyda, Aydoğdu Zekiye, Gürsoy Soner, Yaldız Sadık
Department of Thoracic Surgery, Manisa Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
Department of Thoracic Surgy, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2019 Jun 21;27(3):360-366. doi: 10.5606/tgkdc.dergisi.2019.17284. eCollection 2019 Jul.
This study aims to investigate whether papillary predominant histological subtype can predict poor survival in lung adenocarcinoma.
Between January 2005 and December 2016, a total of 80 patients with papillary predominant subtype lung adenocarcinoma (70 males, 10 females; mean age 60.7 years; range, 42 to 79 years) operated in our clinic were included in the study. These patients were compared with those having lepidic, acinar, and mucinous subtypes. Overall and five-year survival rates were evaluated.
Five-year survival was 40.5% in papillary predominant histological subtype, while this rate was 70.9%, 59.0%, and 66.6% in lepidic, acinar, and mucinous subtypes, respectively. Papillary subtype showed significantly poor survival compared to lepidic (p=0.002), acinar (p=0.008), and mucinous subtypes (p=0.048). In Stage 1 disease, it was more evident (papillary, 47.5%, lepidic 86.9% [p=0.001], acinar 69.3% [p=0.040], and mucinous 90.0% [p=0.050]).
Our study results suggest that papillary predominant subtype predicts poor survival in lung adenocarcinoma and these cases may be candidates for adjuvant treatment modalities even in the earlier stages of disease.
本研究旨在调查乳头状为主的组织学亚型是否可预测肺腺癌患者的不良生存情况。
2005年1月至2016年12月期间，纳入在我院接受手术治疗的80例乳头状为主亚型肺腺癌患者（男性70例，女性10例；平均年龄60.7岁；范围42至79岁）。将这些患者与具有鳞屑状、腺泡状和黏液性亚型的患者进行比较。评估总生存率和五年生存率。
乳头状为主组织学亚型的五年生存率为40.5%，而鳞屑状、腺泡状和黏液性亚型的这一比例分别为70.9%、59.0%和66.6%。与鳞屑状亚型（p=0.002）、腺泡状亚型（p=0.008）和黏液性亚型（p=0.048）相比，乳头状亚型的生存率显著较差。在Ⅰ期疾病中，这种差异更为明显（乳头状亚型为47.5%，鳞屑状亚型为86.9% [p=0.001]，腺泡状亚型为69.3% [p=0.040]，黏液性亚型为90.0% [p=0.050]）。
我们的研究结果表明，乳头状为主亚型可预测肺腺癌患者的不良生存情况，即使在疾病早期阶段，这些病例也可能是辅助治疗模式的候选对象。
