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儿童混合性焦虑障碍的心理药理学:一项基于证据的综述。

Psychopharmacology in Pediatric Mixed Anxiety Disorder: An Evidence-based Review.

作者信息

Naveed Sadiq, Amray Afshan Naz, Jahan Nusrat, Moti-Wala Fatima Bilal, Majeed Muhammad Hassan

机构信息

Dr. Naveed is with the University of Kansas Medical Center in Kansas City, Kansas.

Dr. Amray is with Dow University of Health Sciences in Karachi, Pakistan.

出版信息

Innov Clin Neurosci. 2019 Sep 1;16(9-10):36-43.

PMID:32082949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7009326/
Abstract

Anxiety disorders are the most prevalent psychiatric disorders among youth, with prevalence rates ranging from 25 to 32 percent. These disorders are under-recognized and often undertreated in this population. Anxiety disorders in youth exhibit a chronic and persistent course of symptoms with a higher risk of comorbidities, functional impairment, and worsening of severity. The early recognition and treatment of anxiety disorders in children and adolescents are vital for better long-term outcomes. This article summarizes the evidence-based pharmacologic treatments for mixed anxiety disorders including generalized anxiety disorder, social anxiety disorder, and separation anxiety disorder in children and adolescents based on case reports, case series, open-label trials, and randomized, controlled trials.

摘要

焦虑症是青少年中最普遍的精神疾病,患病率在25%至32%之间。这些疾病在这一人群中未得到充分认识,且往往治疗不足。青少年焦虑症表现出慢性和持续性的症状过程,合并症、功能损害和病情加重的风险更高。儿童和青少年焦虑症的早期识别和治疗对于获得更好的长期预后至关重要。本文基于病例报告、病例系列、开放标签试验以及随机对照试验,总结了针对儿童和青少年混合性焦虑症(包括广泛性焦虑症、社交焦虑症和分离焦虑症)的循证药物治疗方法。

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引用本文的文献

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The current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder.儿科广泛性焦虑障碍的药物治疗现状。
Expert Opin Pharmacother. 2023 May;24(7):835-847. doi: 10.1080/14656566.2023.2199921. Epub 2023 Apr 19.

本文引用的文献

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Frequency and correlates of symptoms of anxiety and depression among young caregivers of cancer patients: a pilot study.癌症患者年轻照料者中焦虑和抑郁症状的频率及相关因素:一项试点研究。
BMC Res Notes. 2018 Aug 31;11(1):631. doi: 10.1186/s13104-018-3740-8.
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The Impact of Antidepressant Dose and Class on Treatment Response in Pediatric Anxiety Disorders: A Meta-Analysis.抗抑郁药剂量和种类对儿童焦虑障碍治疗反应的影响:一项荟萃分析。
J Am Acad Child Adolesc Psychiatry. 2018 Apr;57(4):235-244.e2. doi: 10.1016/j.jaac.2018.01.015. Epub 2018 Feb 8.
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Antidepressant Treatment Duration in Pediatric Depressive and Anxiety Disorders: How Long is Long Enough?儿童抑郁和焦虑症的抗抑郁治疗时长:多长时间才算足够?
Curr Probl Pediatr Adolesc Health Care. 2018 Feb;48(2):31-39. doi: 10.1016/j.cppeds.2017.12.002. Epub 2018 Jan 12.
4
Extended Release Guanfacine in Pediatric Anxiety Disorders: A Pilot, Randomized, Placebo-Controlled Trial.缓释胍法辛治疗儿童焦虑症:一项试点、随机、安慰剂对照试验。
J Child Adolesc Psychopharmacol. 2017 Feb;27(1):29-37. doi: 10.1089/cap.2016.0132. Epub 2017 Feb 6.
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Child/Adolescent anxiety multimodal study: evaluating safety.儿童/青少年焦虑多模式研究:评估安全性。
J Am Acad Child Adolesc Psychiatry. 2015 Mar;54(3):180-90. doi: 10.1016/j.jaac.2014.12.015. Epub 2014 Dec 31.
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Annual research review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents.年度研究综述:儿童和青少年精神障碍全球患病率的荟萃分析。
J Child Psychol Psychiatry. 2015 Mar;56(3):345-65. doi: 10.1111/jcpp.12381. Epub 2015 Feb 3.
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Anxiety disorders and behavioral inhibition in preschool children: a population-based study.学龄前儿童的焦虑症与行为抑制:一项基于人群的研究。
Child Psychiatry Hum Dev. 2015 Feb;46(1):150-7. doi: 10.1007/s10578-014-0460-8.
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24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS).儿童/青少年焦虑多模式研究(CAMS)的24周和36周研究结果。
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Comparison among clomipramine, fluoxetine, and placebo for the treatment of anxiety disorders in children and adolescents.氯米帕明、氟西汀与安慰剂治疗儿童和青少年焦虑症的比较。
J Child Adolesc Psychopharmacol. 2013 Dec;23(10):687-92. doi: 10.1089/cap.2012.0110.
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Treatment with adjunctive N-acetylcysteine in an adolescent with selective serotonin reuptake inhibitor-resistant anxiety.在一名对选择性5-羟色胺再摄取抑制剂耐药的青少年焦虑症患者中使用辅助性N-乙酰半胱氨酸进行治疗。
J Child Adolesc Psychopharmacol. 2012 Dec;22(6):472-3. doi: 10.1089/cap.2012.0066.