靶向抗凋亡BCL-2家族蛋白用于癌症治疗。 - Suppr

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment.

作者信息

Zhang Xuan, Liu Xingui, Zhou Daohong, Zheng Guangrong

机构信息

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL 32610, USA.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL 32610, USA.

出版信息

Future Med Chem. 2020 Apr;12(7):563-565. doi: 10.4155/fmc-2020-0004. Epub 2020 Feb 21.

DOI:10.4155/fmc-2020-0004

PMID:32083493

Abstract

摘要

相似文献

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment.靶向抗凋亡BCL-2家族蛋白用于癌症治疗。

Future Med Chem. 2020 Apr;12(7):563-565. doi: 10.4155/fmc-2020-0004. Epub 2020 Feb 21.

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy.针对抗凋亡 BCL-2 家族的差异化成瘾进行癌症治疗。

Nat Commun. 2017 Jul 17;8:16078. doi: 10.1038/ncomms16078.

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.使用BH3模拟物直接靶向癌症治疗的线粒体凋亡途径——近期成果、当前挑战及未来前景

FEBS J. 2016 Oct;283(19):3523-3533. doi: 10.1111/febs.13714.

Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis.联合抑制 RAC1 和 Bcl-2/Bcl-xL 通过下调 Usp9X/Mcl-1 轴协同诱导胶质母细胞瘤细胞死亡。

Cell Oncol (Dordr). 2019 Jun;42(3):287-301. doi: 10.1007/s13402-019-00425-3. Epub 2019 Mar 11.

Targeting the B-cell lymphoma 2 anti-apoptotic proteins for cervical cancer treatment.针对宫颈癌治疗中的 B 细胞淋巴瘤 2 抗凋亡蛋白。

Future Oncol. 2020 Oct;16(28):2235-2249. doi: 10.2217/fon-2020-0389. Epub 2020 Jul 26.

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.攻克癌症的阿喀琉斯之踵：对抗抗凋亡BCL-2家族成员

FEBS J. 2016 Jul;283(14):2661-75. doi: 10.1111/febs.13472. Epub 2015 Sep 15.

Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.靶向抗凋亡Bcl-2家族成员用于癌症治疗。

Exp Oncol. 2012 Oct;34(3):192-9.

Targeting Bcl-2 for cancer therapy.针对 Bcl-2 进行癌症治疗。

Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188569. doi: 10.1016/j.bbcan.2021.188569. Epub 2021 May 18.

A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.一种新型BH3模拟物通过直接结合抗凋亡Bcl-2家族蛋白（包括磷酸化的Mcl-1）有效诱导黑色素瘤细胞凋亡。

Pigment Cell Melanoma Res. 2015 Mar;28(2):161-70. doi: 10.1111/pcmr.12325. Epub 2014 Dec 18.

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer.在临床前和临床研究中抑制抗凋亡 Bcl-2 蛋白：癌症的当前概述。

Cells. 2020 May 21;9(5):1287. doi: 10.3390/cells9051287.

引用本文的文献

Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive and Study.Bcl2在乳腺癌中的临床病理意义及表达模式：一项综合研究

Saudi J Biol Sci. 2024 Feb;31(2):103916. doi: 10.1016/j.sjbs.2023.103916. Epub 2023 Dec 23.

Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents.一些新型3-芳基-2-硫代-2,3-二氢喹唑啉-4(1)-酮和3-芳基-2-(苄硫基)喹唑啉-4(3)-酮作为抗氧化剂、COX-2、LDHA、α-葡萄糖苷酶和α-淀粉酶抑制剂以及抗结肠癌和凋亡诱导剂的合成与生物学评价

Pharmaceuticals (Basel). 2023 Oct 1;16(10):1392. doi: 10.3390/ph16101392.

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis.Bcl-xL 对于保护潜伏感染 KSHV 的内皮细胞免受病毒诱导的内在凋亡是必需的。

PLoS Pathog. 2023 May 10;19(5):e1011385. doi: 10.1371/journal.ppat.1011385. eCollection 2023 May.

Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis.T 细胞急性淋巴细胞白血病中对 BCL-XL 降解剂 DT2216 的耐药性罕见，与 BCL-XL 蛋白水解减少相关。

Cancer Chemother Pharmacol. 2023 Jan;91(1):89-95. doi: 10.1007/s00280-022-04490-8. Epub 2022 Nov 8.

Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines.木犀草素增强了厄洛替尼对胶质母细胞瘤细胞系的细胞增殖抑制作用和凋亡作用。

Front Pharmacol. 2022 Sep 19;13:952169. doi: 10.3389/fphar.2022.952169. eCollection 2022.

Patent landscape of inhibitors and PROTACs of the anti-apoptotic BCL-2 family proteins.抗凋亡 BCL-2 家族蛋白抑制剂和 PROTAC 的专利全景。

Expert Opin Ther Pat. 2022 Sep;32(9):1003-1026. doi: 10.1080/13543776.2022.2116311. Epub 2022 Sep 1.

Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells.新型2-羟基油酸衍生物和内源性大麻素花生四烯酸乙醇胺对神经母细胞瘤细胞的抗肿瘤作用

Biomedicines. 2022 Jun 29;10(7):1552. doi: 10.3390/biomedicines10071552.

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System.降解致死：泛素-蛋白酶体系统对细胞凋亡的调控。

Cells. 2021 Dec 8;10(12):3465. doi: 10.3390/cells10123465.

Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics.葡萄膜黑素瘤和皮肤黑素瘤中 BCL2 家族成员的表达差异导致对 BH3 模拟物的敏感性不同。

J Invest Dermatol. 2022 Jul;142(7):1912-1922.e7. doi: 10.1016/j.jid.2021.11.035. Epub 2021 Dec 20.

Osthole suppresses the proliferation and induces apoptosis via inhibiting the PI3K/AKT signaling pathway of endometrial cancer JEC cells.蛇床子素通过抑制子宫内膜癌JEC细胞的PI3K/AKT信号通路来抑制其增殖并诱导凋亡。

Exp Ther Med. 2021 Oct;22(4):1171. doi: 10.3892/etm.2021.10605. Epub 2021 Aug 13.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献