Lichtenstein Liljeblad Karin, Kopp Kallner Helena, Brynhildsen Jan
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Obstetrics and Gynaecology, Danderyd Hospital, Stockholm, Sweden.
Eur J Contracept Reprod Health Care. 2020 Apr;25(2):141-146. doi: 10.1080/13625187.2020.1718091. Epub 2020 Feb 21.
The primary objective of the study was to investigate whether the choice of long-acting reversible contraception (LARC) was associated with the risk of abortion over a period of 24 months postpartum. The secondary objective was to analyse whether other significant factors were affecting the risk of abortion during this period. In this retrospective cohort study, we analysed 11,066 women who had delivered in three Swedish cities during 2013 and 2014. Demographic and medical variables were obtained from medical records. Attendance at the postpartum visit, choice of postpartum contraception and history of abortion was noted. Logistic regression analysis was performed to assess factors associated with the risk of abortion. The main outcome measure was the proportion of women with abortion up to 24 months postpartum. Data from 11,066 women were included in the final analysis. Within 12-24 months after delivery 2.5% of women had an abortion. The choice of LARC after childbirth reduced the risk of subsequent abortion (odds ratio 0.74; 95% confidence interval [CI] 0.60, 0.91; = .005). Smoking, age <25 years and have had a previous abortion significantly increased the risk of abortion during follow-up, whereas exclusive breastfeeding decreased the risk. Increasing the proportion of women who choose LARC postpartum could decrease the risk of abortion for up to 2 years after childbirth.
该研究的主要目的是调查长效可逆避孕方法(LARC)的选择与产后24个月内的流产风险是否相关。次要目的是分析在此期间其他显著因素是否会影响流产风险。在这项回顾性队列研究中,我们分析了2013年和2014年在瑞典三个城市分娩的11,066名女性。人口统计学和医学变量从医疗记录中获取。记录产后访视情况、产后避孕方法的选择以及流产史。进行逻辑回归分析以评估与流产风险相关的因素。主要结局指标是产后24个月内流产女性的比例。11,066名女性的数据纳入最终分析。分娩后12 - 24个月内,2.5%的女性发生了流产。产后选择LARC可降低后续流产风险(比值比0.74;95%置信区间[CI] 0.60, 0.91;P = 0.005)。吸烟、年龄<25岁以及既往有流产史会显著增加随访期间的流产风险,而纯母乳喂养则会降低风险。增加产后选择LARC的女性比例可降低分娩后长达2年的流产风险。