Rafei Rayane, Hawli Malaik, Osman Marwan, Dabboussi Fouad, Hamze Monzer
Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.
Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.
J Glob Antimicrob Resist. 2020 Sep;22:334-348. doi: 10.1016/j.jgar.2020.02.005. Epub 2020 Feb 18.
The aim of this review was to provide an updated scenario on the epidemiology of group A streptococci (GAS) in the Middle East and North Africa (MENA) region with a special spotlight on the most prevalent emmtypes and macrolide resistance profiles.
This review briefly summarises the disease burden for GAS in the MENA region.
Whilst the burden of invasive GAS infections is difficult to assess in the MENA region, the GAS prevalence ranged from 2.5% up to 42.4% in pharyngitis patients and from 2.4% up to 35.4% in healthy carriers.emm1, emm12, emm89, emm4, emm28 and emm3were responsible for the major GAS burden in the MENA region. The coverage rate of the new M protein-based vaccine candidate (30-valent) varied from 42% to 100% according to the country. The rate of erythromycin resistance differed substantially between countries from low to moderate or high.
These data add more shreds of evidence on the neglected GAS burden in the MENA region. Systematic surveillance of invasive GAS infections along with molecular characterisation of GAS isolates are strongly recommended to track the trends of circulating clones and to evaluate the potential coverage of vaccine candidates.
本综述旨在提供中东和北非（MENA）地区A组链球菌（GAS）流行病学的最新情况，特别关注最常见的emm型和大环内酯类耐药谱。
本综述简要总结了MENA地区GAS的疾病负担。
虽然在MENA地区难以评估侵袭性GAS感染的负担，但咽炎患者中GAS患病率在2.5%至42.4%之间，健康携带者中GAS患病率在2.4%至35.4%之间。emm1、emm12、emm89、emm4、emm28和emm3是MENA地区GAS主要负担的原因。新型基于M蛋白的候选疫苗（30价）的覆盖率因国家而异，从42%到100%不等。各国红霉素耐药率差异很大，从低到中或高。
这些数据为MENA地区被忽视的GAS负担增加了更多证据。强烈建议对侵袭性GAS感染进行系统监测，并对GAS分离株进行分子特征分析，以追踪循环克隆的趋势并评估候选疫苗的潜在覆盖率。
