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Basophil activation test in cancer patient blood evaluating potential hypersensitivity to an anti-tumor IgE therapeutic candidate.

作者信息

Bax Heather J, Khiabany Atousa, Stavraka Chara, Pellizzari Giulia, Chan Wah Hak Charleen, Robinson Alexandra, Ilieva Kristina M, Woodman Natalie, Naceur-Lombardelli Cristina, Gillett Cheryl, Pinder Sarah, Gould Hannah J, Corrigan Christopher J, Till Stephen J, Katugampola Sidath, Barton Claire, Winship Anna, Ghosh Sharmistha, Montes Ana, Josephs Debra H, Spicer James F, Karagiannis Sophia N

机构信息

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London, UK.

School of Cancer & Pharmaceutical Sciences, King's College London, Guy's Hospital, London, UK.

出版信息

Allergy. 2020 Aug;75(8):2069-2073. doi: 10.1111/all.14245. Epub 2020 Mar 10.

DOI:10.1111/all.14245
PMID:32086828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7581190/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f5/7581190/12a06642471a/ALL-75-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f5/7581190/c6bbcdaf2921/ALL-75-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f5/7581190/12a06642471a/ALL-75-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f5/7581190/c6bbcdaf2921/ALL-75-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52f5/7581190/12a06642471a/ALL-75-na-g002.jpg

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EBioMedicine. 2019 May;43:67-81. doi: 10.1016/j.ebiom.2019.03.080. Epub 2019 Apr 5.
2
Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer.抗叶酸受体α导向抗体疗法限制三阴性乳腺癌的生长。
Clin Cancer Res. 2018 Oct 15;24(20):5098-5111. doi: 10.1158/1078-0432.CCR-18-0652. Epub 2018 Aug 1.
3
An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.
Non-Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First-In-Class IgE Antibody Recognising Folate Receptor Alpha.
与MOv18 IgE相关的非过敏性荨麻疹皮肤反应，MOv18 IgE是一种识别叶酸受体α的首创IgE抗体。
Allergy. 2025 Mar 6. doi: 10.1111/all.16514.
4
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial.表达叶酸受体-α的晚期实体瘤患者中 IgE 抗体 MOv18 的安全性和抗肿瘤活性：一项 I 期试验。
Nat Commun. 2023 Jul 25;14(1):4180. doi: 10.1038/s41467-023-39679-9.
5
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4.针对黑色素瘤相关抗原硫酸软骨素蛋白聚糖 4 的 IgE 抗体的抗癌抗炎作用。
Nat Commun. 2023 Apr 25;14(1):2192. doi: 10.1038/s41467-023-37811-3.
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Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.叶酸受体α在卵巢癌组织和患者血清中与疾病负担和治疗结果相关。
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