[Changes in biological properties of malignant melanoma B-16 after transplantation to (CBA x C57Bl/6)F1 mice].

The primary tumour properties are studied for their effect on the recurrent tumour growth and metastatic spreading after chemotherapy. Serial transplantation of the B16 melanoma to (CBA X C57Bl/6)F1 mice induced gradual changes in tumour malignancy. With an increase of the generation number the metastatic activity of hybrid mice rises and chemotherapeutic sensitivity lowers. The thirty-first and the fifty-fourth tumour generations after the chemotherapy metastasize earlier and the number of metastases increases more rapidly as compared with the recurrence of the primary tumour. The metastatic potential of recurrent tumours increases with the number of generations in hybrid mice.